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ProteomicsProtein kinase C-beta regulates environment mediated drug resistance in B cell malignancies
Environment-mediated drug resistance (EMDR) limits the efficacy of cancer therapies by providing anti-apoptotic signals from a non-malignant microenvironment to tumour cells. We show that EMDR is regulated by protein kinase C in stromal cells is required for EMDR. We used plasma membrane profiling t...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD011062 | Pride
Cancer Emdr Stromal cells Plasma membrane 
ProteomicsVHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.
Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074426 | Pride
Sting Cbf-β Vhl Clear cell renal cell carcinoma Type i interferon 
ProteomicsQuantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals novel targets of viral immune modulation
Kaposi’s Sarcoma associated herpesvirus (KSHV) is an oncogenic human virus and leading cause of mortality in HIV infection. Reactivation of KSHV from latent to lytic stage infection initiates a cascade of viral gene expression, and here we show how these changes remodel the host cell proteome to ena...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2021-08-23 | PXD021387 | Pride
Kshv 
ProteomicsQuantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals novel targets of viral immune modulation
Kaposi’s Sarcoma associated herpesvirus (KSHV) is an oncogenic human virus and leading cause of mortality in HIV infection. Reactivation of KSHV from latent to lytic stage infection initiates a cascade of viral gene expression, and here we show how these changes remodel the host cell proteome to ena...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-05-26 | PXD017365 | Pride
Proteomics Kshv Immune modulation 
ProteomicsAntagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest
The seminal description of cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. As well as APOBEC3G and its homologues, however, we have recently discovered that Vif is also able to degrade the PPP2R5 family of re...
ORGANISM(S): Homo sapiens (Human) 
2020-04-17 | PXD018271 | Pride
Hiv Pp2a Proteomics Vif 
ProteomicsNeural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells.
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it is now clear that transplanted NSCs operate via multiple mec...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD024368 | Pride
Exosomes 
ProteomicsRegulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
The regulation of membrane lipid composition is critical for cellular homeostasis. Cells are particularly sensitive to phospholipid saturation, with increased saturation causing membrane rigidification and lipotoxicity. How mammalian cells sense membrane lipid composition and reverse fatty acid (FA)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-10 | PXD034835 | Pride
Ap-ms Tmt Oritrap fusion 
ProteomicsAltered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination
Myelination of axons enables efficient signal propagation in neurones. Myelin is a multi-layered membrane that wraps around neuronal axons forming extremely tight contacts that insulate the axon. Tight contact between the axon and myelin sheath is mediated by specific plasma membrane proteins and li...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD036727 | Pride
Galactosylceramide Neurofascin Myelination Sulfatide Krabbe disease 
ProteomicsSARS-CoV2 manipulates multiple NK ligands and inhibits NK activation, but this can be overcome by ADNKA, which is strongly activated by non-Spike targeting antibodies
SARS-CoV2 is recognised the antagonise the interferon response, and functioning interferon responses are critical in determining the severity of disease. However, whether the virus antagonises cellular immunity has not been determined. We used quantitative plasma membrane proteomics in lung epitheli...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD025000 | Pride
Sars-cov2 Nk ligands Adnka 
ProteomicsNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
The Wnt-signalling pathway is one of the core de-regulated pathways in chronic lymphocytic leukemia (CLL), activated in a subset of patients by somatic coding mutations. Here we describe an alternative mechanism of Wnt-activation in malignant B cells, mediated by Notch2 activity in mesenchymal strom...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD010401 | Pride
Wnt Notch Cll Plasma membrane 
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