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ProteomicsTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins Revealed Potential Crosstalk between N6-Methyladenosine and Other RNA Modifications
N⁶-methyladenosine (m6A) and its reader, writer, and eraser (RWE) proteins assume crucial roles in regulating the splicing, stability, and translation of mRNA. To our knowledge, no systematic investigations have been conducted about the crosstalk between m6A and other modified nucleosides in RNA. He...
ORGANISM(S): Homo sapiens (Human) 
2022-09-24 | PXD036032 | Pride
Lc-prm N6-methyladenosine Epitranscriptomic reader Writer and eraser proteins 
ProteomicsTargeted Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Radioresistant Breast Cancer Cells
Epitransciptomic reader, writer and eraser (RWE) proteins recognize, install, and remove modified nucleosides in RNA, which are known to play essential roles in RNA processing, splicing, and stability. Here, we established a liquid chromatography–parallel reaction monitoring (LC-PRM) method for high...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030387 | Pride
Epitransciptomic reader Lc-prm Radioresistant breast cancer Trmt1 Writer and eraser (rwe) proteins 
ProteomicsTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Colorectal Cancer Metastasis
Epitranscriptomic reader, writer and eraser (RWE) proteins are involved in the recognition, installation, and removal, respectively, of chemical modifications in RNA, and aberrant expressions of some of these proteins were found to be associated with cancer initiation and progression. Here, we our r...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030907 | Pride
Epitranscriptomic reader Prm Colorectal cancer metastasis Writer and eraser proteins 
ProteomicsTemporal Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins during Osteogenic Differentiation of Human Embryonic Stem Cells
Osteogenesis is the process of bone formation and is modulated by multiple regulatory networks. With the rapid development of the epitranscriptomics field, RNA modifications and their reader, writer, and eraser (RWE) proteins are shown to be involved in the regulation of various biological processes...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD039249 | Pride
Epitranscriptomic reader Writer and eraser Osteogenesis 
UnknownTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Using Stable Isotope-Labeled Peptides.
Not available
S-EPMC9867940 | biostudies-literature
UnknownTargeted Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Regulated by H3K36me3.
Not available
S-EPMC10372775 | biostudies-literature
UnknownTargeted Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Accompanied with Radioresistance in Breast Cancer Cells.
Not available
S-EPMC8792366 | biostudies-literature
ProteomicsTRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Electron Transport Chain Activities
Melanoma is the fifth most common newly diagnosed cancer in the U.S., where substitution of valine 600 with glutamic acid (V600E) in BRAF is the most frequently observed mutation in melanoma. Vemurafenib is an FDA-approved kinase inhibitor for BRAFV600E; while the drug can elicit effective remission...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD063781 | Pride
Vemurafenib resistance Mitochondrion Melanoma 
UnknownParallel-reaction monitoring revealed altered expression of a number of epitranscriptomic reader, writer, and eraser proteins accompanied with colorectal cancer metastasis.
Not available
S-EPMC9582037 | biostudies-literature
ProteomicsTargeted Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins Regulated by H3K36me3
Trimethylation of lysine 36 on histone H3 (H3K36me3), an epigenetic mark associated with actively transcribed genes, plays an important role in multiple cellular processes, including transcription elongation, DNA methylation, DNA repair, and RNA m6A methylation, etc. Aberrant expression and mutation...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD041343 | Pride
Rna modification H3k36me3 Cultured human cells Lc-ms/ms 
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