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UnknownGut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
Not available
S-EPMC9241845 | biostudies-literature
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using LC-MS/MS
Lobaplatin is a third-generation platinum-based antineoplastic agent and is widely used for osteosarcoma treatment before and after tumor removal. However, treatment failure often results from lobaplatin drug resistance. In our study, we found that SaOS-2 and SOSP-9607 osteosarcoma cells became less...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD021564 | Pride
Human Lobaplatin Rhil-6 Osteosarcoma Liquid chromatography-tandem mass spectrometry 
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using Quantitative Phosphoproteome Analysis
IL-6 plays a pivotal role in the process of drug resistance to kinds of chemotherapeutics including lobaplatin. However, the underlying changes of phosphoproteins and related signaling pathways in the posttranslational modification level is still uncover. In our study, a quantitative phosphoproteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025970 | Pride
Human Phosphoproteome analysis Lobaplatin Il-6 Osteosarcoma 
ProteomicsDICAR+/- mouse heart Label free LC-MS
The level of ubiquitin protein of the heart of DICAR+/- compared with wild type
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037732 | Pride
Heart Lc-msms 
MetabolomicsFecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus
The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patien...
2020-01-30 | MTBLS916 | MetaboLights
UnknownTwo gap-free genomes of Argentina provide insights into their genetic relationships.
Not available
S-EPMC12320355 | biostudies-literature
TranscriptomicsSystematic reconstruction of molecular cascades regulating growth plate development using single-cell RNA-seq
The growth plate, which comprises sequentially differentiated cell layers, is a critical structure for bone elongation and regeneration. Although several key regulators in growth plate development have been identified using primarily genetic perturbation, the systematic understanding is still limite...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-76157 | biostudies-arrayexpress
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
ProteomicsIdentification of a biomarker to predict doxorubicin/cisplatin chemotherapy efficacy for osteosarcoma patients by 4D data-independent acquisition (DIA) mass spectrometry with parallel reaction monitoring (PRM) verification
We analyzed the differentially expressed proteins in 37 resected tissue samples from osteosarcoma patients using paraffin- embedded specimens and 4D data-independent acquisition (DIA) quantitative mass spectrometry to investigate biomarkers for predicting the efficacy of doxorubicin/cisplatin chemot...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051097 | Pride
Osteosarcoma  doxorubicin/cisplatin chemotherapy efficacy  data-independent acquisition (dia) mass spectrometry with parallel reaction monitoring (prm)  ctsg  neutrophil extracellular traps (nets) 
ProteomicsTreachery of hepatic protector triggers Notch signaling to promote hepatocyte-originated cholangiocarcinoma
Here, we found mesencephalic astrocyte-derived neurotrophic factor (MANF), a hepatic protector, was upregulated in human ICC tissues and sleeping beauty transposon (SBT) or thioacetamide (TAA)-induced mice ICC tissues. We verified the oncogenic role of MANF in ICC using cell lines overexpressing/kno...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048451 | Pride
Hepatocytes Ip-ms Hucct1 Notch Cholangiocarcinoma Ck19 
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