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ProteomicsEffects of ALS-associated tRNA-derived stress-induced RNA on the transcriptomic and proteomic profile of primary neurons in vitro
LtRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-28 | PXD046961 | Pride
Transcriptome Proteome Als Rna Neurons. 
ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
Proteomicsproteome and pathway effects of chronic haoperidol treatment in mouse hippocampus
Seven male C57BL/6 mice, at 10 weeks of age, were injected daily intraperitoneally with 0.5 mg/kg of haloperidol, for 28 days. A control group of six animals was injected with vehicle only (saline).
ORGANISM(S): Mus musculus (Mouse) 
2015-11-30 | PXD002250 | Pride
Chronic haloperidol treatment Mouse hippocampus Antipsychotics 
ProteomicsMacrophage PAK2 controls the SIRPα immune checkpoint via cytoskeletal dynamics and endocytic trafficking
Professional phagocytes are essential for immunomodulation, antimicrobial control, and initiation and resolution of inflammation. These cells rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity requires a network of positive and negative regulators to control...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-31 | PXD062325 | Pride
Pak2 Endocytic trafficking. Sirpα immune checkpoint Macrophage 
ProteomicsMitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental disorders such as Fragile X syndrome. In contras...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025289 | Pride
Faims Orbitrap Lc-msms 
ProteomicsOXPHOS TARGETING OF MYCN-AMPLIFIED NEUROBLASTOMA
High risk - neuroblastoma (HR-NB) is a pediatric solid tumor with high lethality. Half of HR-NB are driven by MYCN gene amplification (MNA). These HR-NBs require high dosage chemotherapy and often relapse. Moreover, current therapies can cause severe long-term side effects and new therapies are urge...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD069621 | Pride
Neuroblastoma Dpi Mitoq Childhood cancer Combination therapy Metabolism. Oxidative stress 
ProteomicsCell specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges for targeted clinical interventions due to prevalent KRAS mutations, rendering PDAC resistant to RAF and MEK inhibitors (RAFi and MEKi). In addition, responses to targeted therapies vary between patients. Here, we explored the ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD047912 | Pride
Pancreatic ductal adenocarcinoma  raf inhibitors  drug combination  mapk pathway  synergy  targeted therapy resistance  kras mutation 
UnknownReconstructing Asian faunal introductions to eastern Africa from multi-proxy biomolecular and archaeological datasets.
Not available
S-EPMC5560628 | biostudies-literature
UnknownPalaeogenomic analysis of black rat (Rattus rattus) reveals multiple European introductions associated with human economic history.
Not available
S-EPMC9064997 | biostudies-literature
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