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ProteomicsMetabolite-protein covariation architecture identifies a cysteine shunt regulating liver cholesterol
Protein regulation of metabolic processes is foundational to biology. Here we develop a mass spectrometry-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues. This Metabolite Protein Covariation Architectu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD065355 | Pride
Lrrc58 Metabolism Cdo1 Do mice Cysteine Lasso Proteomics 
ProteomicsDiverse bacterial pattern recognition receptors sense the core phage proteome
Recognition of foreign molecules inside cells is critical for immunity across all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic NOD-like receptors (NLRs), play a central role in this process. In bacteria and archaea, although several STAND families sense phage prote...
ORGANISM(S): Salmonella enterica Escherichia coli Escherichia phage T1 
2026-06-10 | PXD079457 | Pride
Seavs7  stand ntpase  bacterial immunity  antiphage defense  phage major capsid protein  ef-tu  affinity purification mass spectrometry  pulldown proteomics  tmtpro 
ProteomicsUCP1-dependent depletion of liver extracellular succinate antagonizes inflammatory pathogenesis
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide and is intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD and is thought to contribute to tissue fibrosis and disease pathogenesis. Uncoupling protein 1 (UCP1) is excl...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD024717 | Pride
Inflammation Thermogenesis Ucp1 Liver Bat 
ProteomicsLactate regulates cell cycle and proliferation by remodeling the anaphase promoting complex
Lactate is abundant in rapidly dividing cells, due to the requirement for elevated glucose catabolism to support proliferation. However, it is not known whether accumulated lactate affects the proliferative state. Here, we deploy a systematic approach to determine lactate-dependent regulation of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD036641 | Pride
Tpp Lactate Cell cycle 
ProteomicsArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Obesity is a polygenic disorder with variable penetrance in the general population. Brown adipose tissue (BAT) is a major regulator of energy expenditure and metabolic physiology due to a specialized proteome that orchestrates futile metabolic cycles, which could be leveraged to treat obesity. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-08 | PXD036947 | Pride
Diversity outbred Qtl Physiology Metabolic disease Network Proteome Obesity Phenotype 
ProteomicsA quantitative tissue-specific landscape of protein redox regulation during aging
Mammalian tissues engage in specialized physiology that is regulated by post-translational protein modification. A major mode of protein regulation is initiated by reactive oxygen species (ROS) that reversibly modify protein cysteine residues. ROS regulate a myriad of biological processes and ROS ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD017050 | Pride
Cpt Redox Aging Cysteine proteomics 
ProteomicsMonocarboxylate transporters facilitate succinate uptake into brown adipocytes
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate succinate uptake in these adipocytes remain undefined. Here ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-10 | PXD048056 | Pride
Succinate Brown adipose tissue Thermogenesis Mct1 Bat 
ProteomicsCysteine 253 of UCP1 regulates energy expenditure and adipose tissue inflammation
Uncoupling protein 1 (UCP1) is thought to be a major regulator of whole-body energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss of function model has recently been shown to have destructive effects on the entire electron transport chain of thermogenic fat. As such, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-15 | PXD029270 | Pride
Sex-dependent Thermogenesis Inflammation Ucp1 Adipose 
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