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UnknownFGF22 deletion causes hidden hearing loss by affecting the function of inner hair cell ribbon synapses.
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S-EPMC9366910 | biostudies-literature
ProteomicsAggregated proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. Through aggregated proteome, we aim to identify DE proteins more associated with plaques by MDK knockout.
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD045746 | Pride
Mdk  aggregated proteome  mice 
ProteomicsWhole proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. AD mouse model of MDK knockout was established to provide the animal tool to investigate the effect of MDK on AD. Through proteome, we aim to study the Aβ change and identify the DE proteins by MDK knockout to know how...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD046539 | Pride
Whole proteome Mdk Mice 
ProteomicsProteome-wide pulse labeling reveals amyloid-impaired protein degradation in Alzheimer’s disease
We here present a large-scale proteome-wide profiling of protein turnover in Alzheimer's disease mice model. We integrated in vivo pulse-SILAC labeling and TMT multiplexing with novel mass spectrometry to precisely measure protein half-lives.
ORGANISM(S): Mus musculus (Mouse) 
2024-10-28 | PXD031830 | Pride
Alzheimer’s disease Tmt Protein turnover Sialc 
Proteomicslarge scale brain proteome profiling of 3xtg mice
A large scale profiling of 3xtg mouse brain to invetigate the AD proteomic phenotype.
ORGANISM(S): Mus musculus (Mouse) 
2024-06-25 | PXD053314 | Pride
Mouse Brain Tmt 
ProteomicsIntegrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity
Autophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-06-22 | PXD048730 | Pride
Mass spectrometry Neuron Autophagy degradation Integrated proteomics Tandem mass tag Lc-ms/ms 
ProteomicsEvaluation of a Pooling Chemoproteomics Strategy with an FDA-approved Drug Library
Chemoproteomics is a key platform for characterizing the mode of action (MoA) for compounds, especially for targeted protein degraders such as proteolysis targeting chimerics (PROTACs) and molecular glues. With deep proteome coverage, multiplexed tandem mass tag-mass spectrometry (TMT-MS) can tackle...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033780 | Pride
Mass spectrometry  proteomics  chemoproteomics  tandem mass tag  pooling strategy  protac  molecular glue  targeted protein degeneration  fda library 
ProteomicsProfiling of the cortical brain proteome in WT, KO, FAD and FAD/KO mice by TMT-LC/LC-MS/MS
Proteomic analysis of 5xFAD/Mdk-KO mouse brain reveals proteome-wide changes. This study investigates the impact of midkine (MDK) knockout in 5xFAD mouse model using comprehensive mass spectrometry-based whole proteome profiling. The data demonstrates significant alterations in amyloid formation and...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD061103 | Pride
Tmt-lc/lc-ms/ms Mdk Mouse Brian 
ProteomicsProfiling of the detergent-insoluble proteome of the cortical brain tissues by TMT-LC/LC-MS/MS
Mass spectrometry analysis of insoluble proteome from 5xFAD/Mdk-KO mouse brain. This study examines the insoluble protein fraction, focusing on aggregation-prone proteins including Aβ and its associated proteins. The data reveals significant accumulation of Aβ-correlated proteins and microglial comp...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD061104 | Pride
Tmt-lc/lc-ms/ms Ad Mdk Mouse Detergent-insoluble 
ProteomicsDeep serum proteomics detects sex-influenced signature in a murine model of Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is categorized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. By using mouse models and performing In-depth analysis of the serum proteome has the potential to identify biomarke...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD044306 | Pride
Proteomics Alzheimer’s disease Mass spectrometry Plasma Serum Proteome Tandem mass tag Biomarker 
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