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ProteomicsThe Study of ATRA-Induced Differentiation of the HL-60 Cell Line
Shotgun mass-spectrometric experiment was performed with HL-60 cells induced to differentiation at 0, 3, 24, 48 and 96h after ATRA treatment. Obtained data has been used for label-free quantification by SPIRE platform based on spectral count. Results on proteome profiling were used for up-stream reg...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD006768 | Pride
Proteomics Atra Time-course study Differentiation Hl60 cell line 
ProteomicsSpace mice re-adaption - Re-adaption on Earth after Spaceflights Affects the Mouse Liver Proteome
Harsh environmental conditions including microgravity and radiation during prolonged spaceflights are known to alter hepatic metabolism. Our studies have focused on the analysis of possible changes in metabolic pathways in livers of mice which experienced 30 days of spaceflight with and without an a...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-22 | PXD005102 | Pride
Metabolism Spaceflight Re-adaption Mice Liver 
ProteomicsProteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment
Searching for new strategies of acute myeloid leukemia (AML) treatment is of particular interest. Cell lines, e. g. HL-60 and NB4, represent model systems to study molecular features of leukemic cells. The all-trans-retinoic acid (ATRA) has proven itself to be an effective treatment for one of AML s...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050317 | Pride
Nb4 cell line K562 cell line Atra Tmt labeling Time-course experiment Hl-60 cell line Proteome 
ProteomicsNuclear proteomics of induced granulocytic differentiation
The nuclear proteome harbors a sheer number of regulatory proteins, including transcription factors (TFs). Profiling of nuclear proteome during all-trans-retinoid acid(ATRA)-induced differentiation of HL60 cells allows to unveil molecular mechanisms of granulocytic maturation. It is especially impor...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035281 | Pride
Atra Tmt Hl60 Nuclei Proteome 
ProteomicsMass-spectrometry analysis of secretome and extracellular vesicles derived from lung and colorectal cell lines
We conducted a proteomic analysis of secretome and EV samples isolated from the conditioned medium of lung cancer LC (A549, NCI-H23, and NCI-H460) and CRC (Caco2, HCT116, and HT-29) cell line models.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057205 | Pride
Caco2 And ht-29 cell lines Hct116 Nci-h460 Extracellular vesicles A549 Nci-h23 Lung cancer Secretome Colorectal cancer 
ProteomicsProteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines: whole cell lysate vs. extracellular vesicles
The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screenin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020454 | Pride
Extracellular vesicles  exosomes  proteomics  mass-spectrometry  colon cancer  lung cancer  biomarkers 
ProteomicsProteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines:extracellular vesicles only
The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screenin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020467 | Pride
Extracellular vesicles  exosomes  proteomics  mass-spectrometry  colon cancer  lung cancer  biomarkers 
ProteomicsShotgun mass-spectrometry of cerebrospinal fluid (liquor) obtained from patients with vestibular schwannoma
Cerebrospinal fluid (liquor) samples (N = 44) have been derived from patients with vestibular schwannoma that comprises about 10% of all intracranial tumors. Applying high resolution tandem mass-spectrometry 525 proteins were identified with high confidence (at least 2 peptides per protein, FDR <1%)...
ORGANISM(S): Homo sapiens (Human) 
2025-01-16 | PXD037746 | Pride
Human Cerebrospinal fluid Proteomics Hypoglossal schwannoma High-resolution mass-spectrometry 
ProteomicsExome-based proteogenomics of HEK-293 human cell line: coding genomic variants identified at the level of shotgun proteome
Genomic and proteomic data were integrated into the proteogenomic workflow to identify coding genomic variants of Human Embryonic Kidney 293 (HEK-293) standard cell line at the proteome level. Shotgun proteome data published by Geiger et al (2012) and obtained in this work for HEK-293 were searched ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080712 | MassIVE
ProteomicsAssessment of Serological Early Biomarker Candidates for Lung Adenocarcinoma by using Multiple Reaction Monitoring-Mass Spectrometry
Purpose: Serum markers that enable diagnosis in the early stage of lung cancer have not been discovered. We have developed a LC-MRM-MS assay for the identification of potential early marker proteins for lung adenocarcinoma. Experimental design: LC-MRM-MS assay was used for measuring the level of 35 ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD014683 | panorama
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