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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsMass spectrometry analysis of proteins interacting with STC1
identify the potential partners of STC1 at the protein level, we performed mass spectrometry on B16-F10 tumor cells stably expressing FLAG-tagged STC1.
ORGANISM(S): Mus musculus (Mouse) 
2020-12-23 | PXD023251 | Pride
Ms Ip Stc1 B16-f10 tumor cells 
ProteomicsPAD4 controls tumor immunity via restraining the MHC-II machinery in macrophages
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood if and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we found that peptidylarginine deiminase 4 (PAD4) manifested the highe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD049188 | Pride
T cell Macrophage Pias Checkpoint Mhc Immunotherapy Tumor Pad4 Citrullination Stat1 
TranscriptomicsModerate stress acclimation provides immunity to stress by rewiring regulatory networks and inducing genes with protective functions in Cassava
Stress acclimation is an effective mechanism that plants acquired for adaption to dynamic environmental conditions. After undergoing cold acclimation, plants become more tolerant to cold stress. In order to understand the mechanism of cold acclimation, we performed a systematic, comprehensive study ...
ORGANISM(S): Manihot esculenta 
2014-08-18 | E-GEOD-52176 | biostudies-arrayexpress
TranscriptomicsGene expression profiling reveal different molecular pattern in G-protein coupled receptor protein signaling pathway between early- and late-onset preeclampsia
Background: Early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) has been regarded as two different phenotypes with heterogeneous manifestation. The underlying mechanisms remain elusive. Aim to gain insight into the pathogenesis of the two traits, we analyzed the placental gene express...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-74341 | biostudies-arrayexpress
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
TranscriptomicsIsraeli acute paralysis virus – what we have learned about the virus since mysterious disappearance of the US honey bees known as Colony Collapse Disorder (CCD) in 2006
There were important gaps in our knowledge of Israeli acute paralysis virus (IAPV), when IAPV was tightly linked to bee Colony Collapse Disorder (CCD), the mysterious disease that, starting in 2006-2007, has been wiping out honey bees in the US. To fill in these gaps we studied the molecular basis ...
ORGANISM(S): Apis mellifera 
2014-04-08 | E-GEOD-46278 | biostudies-arrayexpress
ProteomicsSerum proteomics of individuals with MASLD under resistance starch intervention
Searching for baseline proteins that contribute to the individual response to RS intervention
ORGANISM(S): Homo Sapiens 
2025-09-24 | PXD068798 |
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