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ProteomicsSubstrates of human Sec62/Sec63 complex
The Sec61-associated Sec62/Sec63 complex supports translocation of only a subset of precursor polypeptides, i.e. in a substrate-specific manner. To characterize Sec62/Sec63-dependent precursors, we combined siRNA-mediated Sec62 or Sec63 depletion in Hela cells or CRISPR/Cas9-mediated knock-down in H...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD012078 | Pride
Hela Er protein import Hek 293 
ProteomicsTargeting of precursor polypeptides to the human ER
Various pathways can target nascent or fully synthesized precursor polypeptides to the human endoplasmic reticulum (ER). Typically, they involve cytosolic proteins or complexes and their respective receptors on the ER surface. The signal recognition particle (SRP) and the heterodimeric SRP-receptor...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD011993 | Pride
Hela Snd2 Wrb/caml Sr 
ProteomicsPolypeptide targeting to distinct areas of the human ER
There is at least one additional targeting pathway for proteins to the human endoplasmic reticulum, which involves a cytosolic as well as an ER-membrane resident receptor, belonging to the family of PEX proteins. In contrast to the precursor protein targeting pathways, the additional pathway targets...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD012005 | Pride
Hela Pex3 
ProteomicsSubstrates of human TRAP complex
While the Sec61-complex in the membrane of the human endoplasmic reticulum facilitates translocation of all precursor polypeptides with amino-terminal signal peptides or transmembrane helices, the Sec61-associated translocon-associated protein (TRAP)-complex supports translocation of only a subset o...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD008178 | Pride
Sec61 complex Ms Hela cells Er protein import Trap complex 
TranscriptomicsEffects of SPOP on gene expression in prostate cancer
SPOP is a ubiquitin ligase adaptor frequently mutated in prostate cancer. It is involved in ubiquitination and degradation of substrate proteins. We examined the impact of wild-type and mutant SPOP on the transcriptional profile of prostate cancer cells. We cloned several naturally occurring (in hum...
ORGANISM(S): Homo sapiens 
2014-10-10 | E-GEOD-59432 | biostudies-arrayexpress
TranscriptomicsSAGE libraries from cell bodies and axons of NGF-differentiated sympathetic neurons
The subcellular localization of specific mRNAs is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. In neurons, mRNA trafficking and local protein translation in dendrites provides an important mechanism that mediates synaptic ...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-13788 | biostudies-arrayexpress
UnknownContribution of the IdyllaTM System to Improving the Therapeutic Care of Patients with NSCLC through Early Screening of EGFR Mutations.
Not available
S-EPMC8628756 | biostudies-literature
UnknownVariation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Not available
S-EPMC3434228 | biostudies-literature
UnknownPathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.
Not available
S-EPMC12357302 | biostudies-literature
UnknownPrevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic: a cross-sectional population-based study in Geneva, Switzerland.
Not available
S-EPMC11749439 | biostudies-literature
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