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We identified an Hsp40 Ydj1 / Hdj2 ortholog in T. gondii, which is involved in various biological roles in T. gondii as deduced from its interactome and analysis of the ΔCXXX mutant. Among these roles are differentiation and DNA damage, as well as metabolic pathways such as translation and energy ge...
ORGANISM(S): Toxoplasma gondii 
2023-05-10 | PXD024656 | Pride
PD-1 immune checkpoint blockade (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression. In a whole-genome, dual-marker FACS-based CRISPR/Cas9 screen in primary murine CD8 T cells, we found that inactivation of the EMP24/GP25L/p24 protein family, mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD026984 | Pride
T-cell dysfunction genes limit antitumor activity and may serve as therapeutic targets. It has not been systematically studied whether there are regulators that either uniquely or broadly contribute to T-cell fitness. We performed genome-scale CRISPR/Cas9 knockout screens in primary CD8 T-cells to u...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD043545 | Pride
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