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ProteomicsCathepsin S in Mycobacterium avium subsp. paratuberculosis Infected Dairy Cows
In this study, samples of 16 dairy cows from a MAP infected farm were used. Serum, milk and fecal samples were collected. Categorizing these cows into two groups based on their MAP infection status different standard methods for detection MAP were applied. Healthy controls showed no positive results...
ORGANISM(S): Bos taurus (Bovine) 
2024-06-22 | PXD048042 | Pride
Preomics Serum Label-free mass spectrometry 
ProteomicsMolecular classification of the placebo effect in nausea by mass spectrometry
In this proof-of-concept study, we tested whether placebo effects can be monitored and predicted by plasma proteins. In a randomized controlled design, 90 participants were exposed to a nauseating stimulus on two separate days and were randomly allocated to placebo treatment or no treatment on the s...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020563 | Pride
Dia-ms Plasma Nausea Placebo 
ProteomicsMulti-platforms approach for plasma: complementarity of Olink PEA technology to DIA-based mass spectrometry-based protein profiling
Plasma proteome is the ultimate target for the biomarker discovery. It stores an endless amount of information on the pathophysiological status of a living organism, which however is still difficult to comprehensively access. The high structural complexity of the plasma proteome can be addressed by ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD020261 | Pride
Olink technology Dia-ms Kora: cooperative health research in the region of augsburg 
ProteomicsProteomics on sera of mice following local high-dose heart irradiation
Background and Purpose: Cardiotoxicity is a well-known adverse effect of radiation therapy. Measurable abnormalities in the heart function indicate advanced and often irreversible heart damage. Therefore, early detection of cardiac toxicity is necessary to delay and alleviate the development of the ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024446 | Pride
Heart Proteomics Radiation therapy Inflammation Cytokines Data-independent acquisition Ionizing radiation Biomarker 
ProteomicsProteomics to study cardiotoxic noxae in adults
The heart tissue is a potential target of various noxae contributing to the onset of cardiovascular diseases. However, underlying pathophysiological mechanisms are largely unknown. Human stem cell-derived models are promising, but a major concern is the cell immaturity when estimating risks for adul...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028099 | Pride
Cardiomyocytes Proteomics Maturation Ionizing radiation 
ProteomicsThe proteome of native adult Müller cells from the murine retina
We set out to first establish and validate a novel rapid method of enriching adult Müller cells, which yields sufficient cell numbers for proteomic profiling while keeping cells viable and morphologically, as well as physiologically fully intact. From these preparations we collected a comprehensive ...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-15 | PXD002247 | Pride
Lc-msms Macs Retina Fasp Muller glia cell 
ProteomicsEngineering of human myotubes towards a mature metabolic and contractile phenotype
Skeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current skeletal-muscle-models in vitro are incapable of fully recapitulating its physiological functions especially regarding exercise. Supplementation of IG...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043200 | Pride
Myotubes Mass spectrometry Igf Immunohistochemistry 
ProteomicsImpaired stability of tumor cells after targeting of lactate/pyruvate metabolism investigated by shotgun proteomics
Overexpression of heat shock proteins (HSPs), especially the major stress-inducible 72 kDa heat shock protein 70 (Hsp70), in malignant tumor cells is associated with therapeutic resistance. The heightened metabolic demand in tumor cells (Warburg effect) increases lactate dehydrogenase (LDH) activity...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026078 | Pride
Lc-msms Heat shock proteins Lactate/pyruvate metabolism Ldha/b double knockout Membrane hsp70 expression Radiosensitivity 
ProteomicsIron Toxicity targeting mitochondrial Iron-Sulfur cluster enzymes
Unregulated nutritional iron absorption in hereditary hemochromatosis causes its overload, especially in liver. While this may lead to severe pathology, intriguingly, it may also frequently go unrecognized. Indeed, profound iron loading in hemochromatosis Hfe knockout mice and hemochromatosis Huh7 h...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD070837 | Pride
Iron-sulfur cluster enzymes Mitochondria Hemochromatosis Trace metals Methanobactin Liver Iron overload 
ProteomicsLC-MSMS on mouse retina to investigate photoreceptor degeneration
Intraocular anti-VEGFA injections are frequently used to counteract neovascularization in diseases such as the neovascular (wet) form of age-related macular degeneration (AMD) or proliferative diabetic retinopathy. However, in the clinical context, patients with atrophic (dry) and wet AMD in the sam...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD066263 | Pride
Vegfr2 deletion Photoreceptor Lc-msms 
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