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ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
ProteomicsUMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes
Universal Minicircle Sequence binding proteins (UMSBPs) are CCHC-type zinc-finger proteins that bind the single-stranded G-rich UMS sequence, conserved at the replication origins of minicircles in the kinetoplast DNA, the mitochondrial genome of trypanosomatids. Trypanosoma brucei UMSBP2 has been re...
ORGANISM(S): Trypanosoma brucei 
2023-07-20 | PXD030439 | Pride
Trypanosomes Antigenic variation Gene expression Umsbp Chromatin remodeling 
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
ProteomicsThe covalent bonding of beta-2-microglobulin with HLA class I influences the antigenic landscape of cells
Here, we investigate the effect that a constant interaction of beta-2m with HLA-I molecules can have on what antigens and peptides are displayed upon direct- and cross-presentation. When beta-2m is linked to HLA-I molecules the antigenic landscape is modified compared to physiological conditions.
ORGANISM(S): Homo sapiens (Human) 
2026-06-04 | PXD063813 | Pride
Lc-msms Hla-i Immunopeptidome Mhc-i 
TranscriptomicsTranscription profiling of wild type, Pfsir2A knock-out and Pfsir2B knock-out Plasmodium falciparum intra-erythrocytic stages
Pfsir2A and Pfsir2B KOs expression profiling in intra-erythrocytic stages
ORGANISM(S): Plasmodium falciparum 
2008-05-01 | E-TABM-438 | biostudies-arrayexpress
ProteomicsDeep motif deconvolution of HLA-II peptidomes
CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-18 | MSV000096130 | MassIVE
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
UnknownMass Spectrometric Analysis of Antigenic Determinant Glycans of Soybean Glycoprotein Gly m Bd 30K.
Not available
S-EPMC12430132 | biostudies-literature
ProteomicsIdentification of blood MHC-binding peptides in mice after Brucella infection
We infected mice with Brucella, took mouse blood 6 days after infection, MHC binding antigenic peptides were collected by immunoprecipitation method and verified by mass spectrometry
ORGANISM(S): Mus Musculus 
2022-03-27 | PXD032855 |
ProteomicsImmunopeptidome of HeLa-CIITA cells silenced for TAX1BP1(T6BP) expression
CD4+ T lymphocytes play a major role in the establishment and maintenance of immunity. They are activated by antigenic peptides derived from extracellular or newly synthesized (endogenous) proteins presented on the surface of antigen presenting cells (APCs) by the MHC-II molecules. The pathways lead...
ORGANISM(S): Homo sapiens (Human) 
2022-09-22 | PXD024417 | Pride
Human Lc-msms Autophagy receptor 
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