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MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
ProteomicsProteome of ATGL knock-out A549 cells compared to A549 wild type cells
Comparison of ATGL-KO and ATGL-WT A549 cell proteomes
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD007223 | Pride
Human A549 Atgl Lc-ms/ms 
TranscriptomicsRNA-seq analysis of lung-infiltrating neutrophils from WT and Atgl-cKO mice
Atglflox/flox (B6N.129S-Pnpla2tm1Eek/J), S100A8-cre+/- (B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J) mice were obtained from The Jackson Laboratory. Atglflox/flox mice were bred to S100A8-cre+/- mice to generate Atglflox/WTS100A8-cre+/- mice, which were backcrossed onto Atglflox/flox mice to generate Atglflox/...
ORGANISM(S): Mus musculus 
2020-06-28 | E-MTAB-9235 | biostudies-arrayexpress
ProteomicsMutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis
ATGL is the key enzyme in intracellular lipolysis playing a critical role in metabolic and cardiovascular diseases. ATGL is tightly regulated through a known set of protein-protein interaction partners with activating or inhibiting functions in control of lipolysis. However, the binding mode and pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD049436 | Pride
Deep mutagenesis Cidec Plin5 Plin1 Atgl G0s2 Cgi-58 
GenomicsATGL deletion in castration-resistant prostate cancer cell line
ATGL deletion in castration-resistant prostate cancer cell line
PRJNA1016447 | ENA
GenomicsDeep mutational interaction perturbation reveals ATGL contact sites with key regulatory proteins in lipolysis
Deep mutational interaction perturbation of ATGL
PRJEB60025 | ENA
GenomicsExpression data from Club cells of wt/cTg and Atgl KO/cTg
Expression data from Club cells of wt/cTg and Atgl KO/cTg
PRJNA733158 | ENA
ProteomicsProteomics analysis of non-small cell lung cancer cell lines lacking ATGL (ATGL-KO) or MGL (MGL-KO) or expressing both (Control, NTC)
Adipose Triglyceride Lipase (ATGL) and Monoglyceride Lipase (MGL) are two enzymes that contribute to intracellular neutral lipolysis by breaking down triglycerides stored within lipid droplets. Recently, lipid droplet accumulation has been described as a novel hallmark of cancer. While lipid metabol...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD046912 | Pride
H1299 Lipid hydrolysis Lipolysis Nsclc A549 Atgl H358 H441 Mgl Lipase 
GenomicsEffect of ATGL knockdown by siRNA in human umbilical vein endothelial cells
Effect of ATGL knockdown by siRNA in human umbilical vein endothelial cells
PRJNA967015 | ENA
TranscriptomicsTranscription profiling of six tissues from ATGL knock-out versus wild type mice
Gene expression profiling in 6 tissues (white adipose tissue (WAT), brown adipose tissue (BAT), cardiac muscle (CM), liver (LIV), kidney (KID), skeletal muscle (SM)) from ATGL(-/-) mice versus wildtype (ATGL+/+) mice.
ORGANISM(S): Mus musculus 
2008-02-03 | E-MARS-8 | biostudies-arrayexpress
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