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ProteomicsGlycoproteomic analysis of MGL binding protein on acute T cell leukemia cells
O-glycosylation is generally initiated by the transfer of a N-acetylgalactosamine to Ser/Thr residues of proteins, forming the Tn antigen. This truncated surface glycan is expressed at high levels by tumor cells and is associated with higher metastatic behaviour and poor prognosis of patients. The T...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD011307 | Pride
Glycoproteomics Leukemia O-glycosylation Tn-antigen Lectin 
ProteomicsN-glycoproteins have a major role in MGL binding to colorectal cancer cell lines
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide due in part to a high proportion of patients diagnosed at advanced stages of the disease. For this reason, many efforts have been made towards new approaches for early detection and prognosis. Cancer-associated aberrant gl...
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD020344 | Pride
Glycoproteomics  tmt labelling  c-type lectin  colorectal cancer  lacdinac  tn antigen 
ProteomicsCharacterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines
Background The Ca2+-dependent C-type lectin receptor Macrophage Galactose-type Lectin (MGL) is highly expressed by tolerogenic dendritic cells (DC) and macrophages. MGL exhibits a high binding specificity for terminal alpha- and beta-linked GalNAc residues found in Tn, sTn and LacdiNAc antigens. The...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016726 | Pride
: glycoproteomics  c-type lectin  colorectal cancer  lacdinac  tn antigen 
ProteomicsProbing the ovarian cancer O-glycoproteome by the Macrophage Galactose like C-type Lectin (MGL): dissecting novel patterns of immune recognition
Glycosylation, the posttranslational linking of sugar molecules to proteins, is notoriously altered during tumor transformation. More specifically in carcinomas, GalNAc-type O-glycosylation, is characterized by biosynthetically immature truncated glycans present on the cancer cell surface which prof...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017510 | Pride
Ovarian cancer O-glycosylation Cancer immunotherapy Tn antigen Dcs Tumor biomarker 
GenomicsBacillus velezensis strain:MGL-B1
Bacillus velezensis strain:MGL-B1 Genome sequencing
PRJNA1329252 | ENA
ProteomicsProteomics analysis of non-small cell lung cancer cell lines lacking ATGL (ATGL-KO) or MGL (MGL-KO) or expressing both (Control, NTC)
Adipose Triglyceride Lipase (ATGL) and Monoglyceride Lipase (MGL) are two enzymes that contribute to intracellular neutral lipolysis by breaking down triglycerides stored within lipid droplets. Recently, lipid droplet accumulation has been described as a novel hallmark of cancer. While lipid metabol...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD046912 | Pride
H1299 Lipid hydrolysis Lipolysis Nsclc A549 Atgl H358 H441 Mgl Lipase 
GenomicsGene expression data obtained from Oryza sativa adventitious roots (2-6 cm behind the root tip) grown in nutrient solution with (30 mgL-1) and without (3 mgL-1) Si
Gene expression data obtained from Oryza sativa adventitious roots (2-6 cm behind the root tip) grown in nutrient solution with (30 mgL-1) and without (3 mgL-1) Si
PRJNA435596 | ENA
TranscriptomicsNext generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS
To investigate the effect of MGL ligation in monocyte-derived dendritic cell biology, we generated control dendrimers and two different glycodendrimers exposing the MGL ligands αGalNAc or GalNAcβ1-4Gal. αGalNAc and GalNAcβ1-4Gal glycodendrimers were validated in the corresponding manuscript. Monocyt...
ORGANISM(S): Homo sapiens 
2020-02-18 | GSE143699 | GEO
ProteomicsAmniotic fluid glycoproteins as potential ligands for macrophage galactose-type C-type lectin: implications for immunoregulation during pregnancy
Immunity during pregnancy must be precisely balanced, because the mother's body needs to effectively fight pathogens while maintaining tolerance of the semi-allogeneic fetus. Factors that participate in achieving the proper immune balance during pregnancy include glycoproteins that expose sugar resi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD063586 | Pride
Mgl  clec10a  ligands  amniotic fluid 
UnknownGlycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.
Not available
S-EPMC6399673 | biostudies-literature
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