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UnknownControl of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol.
Not available
S-EPMC12371084 | biostudies-literature
ProteomicsIdentification of global inhibitors of cellular glycosylation
Small molecule inhibitors of glycosylation enzymes can be valuable tools for dissecting glycan functions and present great potential as drug discovery candidates. Most screening campaigns for inhibitors of glycosyltransferases have been limited to in vitro enzyme assays using recombinant enzymes, wh...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029623 | Pride
Cell-based glycan array O-glycosylation Sars-cov-2 Compound library screen Glycosylation inhibitor 53 golgi fragmentation Glycosyltransferases 
ProteomicsA novel Golgi-associated Vangl2 Translational variant is required for PCP regulation in vertebrates
First described in Drosophila melanogaster, planar cell polarity (PCP) is a developmental process essential for embryogenesis and development of polarized structures in Metazoans. This signaling pathway involves a set of evolutionarily conserved genes encoding transmembrane (Vangl, Frizzled, Celsr) ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-04-09 | PXD021794 | Pride
Lc-msms Pcp Vangl2 Xenopus 
ProteomicsCircadian Clock Regulation of the Secretory Pathway
Proteins destined for secretion move from the endoplasmic reticulum (ER, the site of synthesis) to Golgi cisternae then onto the cell surface in transport vesicles. Although the mechanism of anterograde and retrograde transport via vesicles is well understood the temporal coordination of transport b...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-28 | PXD013450 | Pride
Mouse Tendon Collagen Protein trafficking 
ProteomicsProteomic analysis of 3T3 murine fibroblast used as feeder-layer
The unfolded protein response (UPR) helps reinstate cellular proteostasis upon an accumulation of misfolded proteins in the endoplasmic reticulum (ER), in part through ER-associated degradation (ERAD). Ube2j2 is an ER-localized E2 ubiquitin-conjugating enzyme that participates in ERAD. We used mass ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-03 | PXD078047 | Pride
Feeder-layer Fibroblast Skin expansion 
ProteomicsAcetyl-CoA flux maintains intracellular crosstalk and modulats engagement of the secretory pathway
Nε-lysine acetylation has emerged as a central mechanism to maintain quality control and protein homeostasis within the Endoplasmic Reticulum (ER) and secretory pathway. The ER acetylation machinery includes AT-1/SLC33A1, a membrane transporter that translocates acetyl-CoA from the cytosol to the ER...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019770 | Pride
Mouse Brain Glycoproteomics Lc-ms/ms 
ProteomicsEffects of human immunoglobulins on Cryptococcus neoformans morphology and proteome
Cryptococcus neoformans (Cn) is the main cause of fungal meningitis (CM) in people living with HIV. Perturbations in levels of normal immunoglobulin (Ig) levels are observed in these individuals, but their association with CM pathogenesis is unclear. Here, we investigated the physical and biological...
ORGANISM(S): Cryptococcus neoformans 
2026-01-26 | PXD072710 | Pride
Igm Cryptococcal capsule Cryptococcus neoformans Human immunoglobulins Igg Hiv Cryptococcal proteome. And iga Glucuronoxylomannan 
ProteomicsAllotype-specific glycosylation and cellular localization of HLA class I proteins
Presentation of self- and foreign peptide antigens by human leukocyte antigen (HLA) complexes at the cell surface is a key process in our immune response. The alpha-chain, the part of the HLA class I complex that contains the peptide binding groove, is one of the most polymorphic proteins in the hum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD023684 | Pride
Glycoproteomics Mhc Hla 
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