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ClinicalAdhesions After Open Versus Laparoscopic Resection of Colorectal Malignancies Detected During Liver Resection
Rationale: Adhesion formation is a frequent complication after abdominal surgery. Adhesion formation might be reduced by laparoscopic surgery, however sound evidence is lacking. Colorectal surgery would be a good clinical model to investigate adhesion formation between open and laparoscopic surgery ...
2134661 | ecrin-mdr-crc
GenomicsJUN promotes abdominal adhesions in mice and humans
JUN promotes abdominal adhesions in mice and humans
PRJNA644557 | ENA
GenomicsSustained-release anti-JUN therapeutic abrogates post-operative adhesions
Sustained-release anti-JUN therapeutic abrogates post-operative adhesions
PRJNA1073436 | ENA
GenomicsMouse Mesothelial cells from peritoneal adhesions
Mouse Mesothelial cells from peritoneal adhesions for the study of RNA-seq MMT-related changes.
PRJEB48465 | ENA
TranscriptomicsJUN promotes abdominal adhesions in mice and humans
Adhesions are fibrotic scars that form between abdominal organs following surgery or infection, and may cause bowel obstruction, chronic pain, or infertility. Adhesions occur post-operatively in 50-90% of all open abdominal operations and as such, represent an enormous clinical problem impacting hun...
ORGANISM(S): Homo sapiens Mus musculus 
2020-07-08 | GSE153929 | GEO
ProteomicsThe composition of reticular adhesions in RPMI-7951 and MDA-MB-435S melanoma cell lines and its comparison with the reticular adhesion composition following talin2 or KANK2 knockdown
Integrins bind extracellular matrix proteins and, when clustered, form integrin adhesion complexes (IACs) that connect to and regulate the cytoskeleton, shaping normal and tumour cell behaviour. In addition to well-known nascent adhesions, focal adhesions (FAs), fibrillar adhesions (FBs), and hemide...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071922 | Pride
Reticular adhesions Kank2 Matrisome Adhesome Melanoma Rpmi-7951 cells Integrin alphavbeta5 Talin2 Mda-mb-435s cells 
ProteomicsCYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
CYRI proteins promote lamellipodial dynamics by opposing Rac1-mediated activation of the Scar/WAVE complex. This activity also supports resolution of macropinocytic cups, promoting internalisation of surface proteins, including integrins. Here, we show that CYRI-B also promotes focal adhesion matu...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062975 | Pride
Vinculin Bio-id Integrins Actin cytoskeleton Erc1 Focal adhesions Paxillin Cyri-b Microtubules 
GenomicsIntraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling.
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling.
PRJNA774989 | ENA
TranscriptomicsSustained-release anti-JUN therapeutic abrogates post-operative adhesions
Post-operative abdominal adhesions are the leading cause of bowel obstruction and a major cause of chronic pain and infertility. Further, adhesion formation complicates any re-operative strategy, increasing the length of surgery and rendering a safe minimally invasive approach impossible. Despite th...
ORGANISM(S): Sus scrofa 
2025-02-06 | GSE255052 | GEO
GenomicsMacrophage accumulations on the injured pulmonary surface accelerate intrathoracic adhesions
Macrophage accumulations on the injured pulmonary surface accelerate intrathoracic adhesions
PRJNA1197516 | ENA
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