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MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
MetabolomicsSerum Metabolomics Reveals Stage-Dependent Metabolic Transitions During CIDR-PGF2alpha-Induced Estrus in Kazak Ewes
This study investigated serum metabolic transitions during CIDR-PGF2alpha-induced estrus synchronization in Kazak ewes using UHPLC-MS/MS untargeted metabolomics. Eighteen Kazak ewes were assigned to three reproductive stages: luteal phase (LP), luteolysis phase (LDP), and estrus phase (OES), with si...
2026-08-09 | MTBLS15117 | MetaboLights
ProteomicsProtein microarray analysis of expression of murine cytokines in spleen interfered with IFN-α and (or) LPS
12 wild-type C57BL/6 (B6) mice were divided into 4 groups: control group, IFN-α group, LPS group, and IFN-α+ LPS group, every group contained 3 mice (n=3). IFN-α was administrated i.p. to IFN-α group and IFN-α+ LPS group once daily (QD) for 7 days at a medium dose of 105units/kg weight, PBS was admi...
ORGANISM(S): Mus musculus 
2012-11-10 | E-GEOD-42183 | biostudies-arrayexpress
ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
ProteomicsIdentification of Alpha-Synuclein Interacting Synaptosomal Proteins
α-Synuclein is an abundant presynaptic protein that when aggregated and dyslocated from the synapse is associated to Parkinson’s disease and dementia. The normal presynaptic function of α-synuclein is unclear as well as the disease triggering mechanism. In order to extend the knowledge of the α-synu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-02-09 | PXD001462 | Pride
Aggregation Synaptosomes Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsCharacterization of protein dynamics after alpha-amanitin exposure in hepatoma cells
Alpha-amanitin (α-AMA) is a cyclic peptide and is one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of α-AMA beyond known mech...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018702 | Pride
Tric Alpha-amanitin Hepatotoxicity Comparative quantitative proteomics 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 4 - controls (7/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002262 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 2 - controls (3/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002258 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 3 - controls (5/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002260 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 1 - controls (1/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002256 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
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