Sort   by:  
 Page size 
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of copy-number alterations in multiple myeloma
Purpose Chromosomal aberrations are a hallmark of multiple myeloma but their global prognostic impact is largely unknown. Methods We performed a genome-wide analysis of malignant plasma cells from 192 newly myeloma patients using high-density, single-nucleotide polymorphism (SNP) arrays to identify...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-12896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD8 T cells in response to P1A antigen expressing tumor cells or cells not expressing 1A antigen
Activation status of CD8 T cells in response to a tumor challenge. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma...
ORGANISM(S): Mus musculus 
2007-12-01 | E-MEXP-1285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NK cells in presence/absence of activated CD8 T cells
we compare NK cells in presence of activated CD8 T cells or not. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma t...
ORGANISM(S): Mus musculus 
2007-11-01 | E-MEXP-1284 | biostudies-arrayexpress
ProteomicsPCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-15 | PXD011044 | Pride
Tnbc- triple negative breast cancer Pi3k- the phosphoinositide 3-kinase Her2/erbb2- human epidermal growth factor receptor 2 Signaling pathways Egfr- epidermal growth factor receptor Combination therapy Pcna- proliferating cell nuclear antigen Multi-targeting therapy Pr- progesterone receptor Mapk- mitogen-activated protein kinase Autophagy Vegf- vascular endothelial growth factor Er- estrogen receptor 
TranscriptomicsGene expression in NKR-P1B+ versus Ly49s3+ rat NK cells
Two major subsets of rat natural killer (NK) cells can be distinguished based on their expression of either the Ly49s3 or the NKR-P1B lectin-like receptor. Ly49s3+ NK cells, but not NKR-P1B+ NK cells, express a wide range of Ly49 receptors. Here, we performed a global gene expression profiling of so...
ORGANISM(S): Rattus norvegicus 
2010-03-18 | E-GEOD-20935 | biostudies-arrayexpress
ProteomicsNucleoside Analogues are Potent Inducers of Bacterial Mutagenesis
Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here we have examined nucleoside analogues (NAs) ...
ORGANISM(S): Escherichia coli 
2021-07-15 | PXD025370 | Pride
Na -clamp Tls Mdr Pol v Nrtis Sos Amr 
ProteomicsAPIM-peptide targeting PCNA improves cisplatin therapy in a rat muscle-invasive bladder cancer model
High mortality rate of muscle-invasive bladder cancer (MIBC) and complexity of disease demand new multi-targeting treatment strategies. Targeting proliferating cell nuclear antigen (PCNA) with a peptide containing the AlkB homologue 2 PCNA interacting motif (APIM), is shown to impair multiple vital ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-09-10 | PXD008724 | Pride
Ay-27 Rat Mib Lfq Assay 
ProteomicsNK-cell derived extracellular vesicles LC-MS/MS
In this study we have compared the proteomic profile of extracellular vesicles (EVs) prepared from primary, human NK cells or the human NK cell lines NK-92 and KHYG-1 cultured for 48hrs in serum-free conditions. EVs were harvested from cells either under resting conditions (culture in IL-15) or upon...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027284 | Pride
Nk-92 Nk cells Il-18 Cd16 Il-12 Khyg-1 Il-15 Lc-ms/ms 
TranscriptomicsGenetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients.
Purpose Despite advances and significant improvement in survival, multiple myeloma (MM) remains incurable and nearly all patients relapse after treatment. Previous studies have shown a complex spectrum of diverse genetic alterations in almost all patients, but evolution of genomic rearrangements th...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-25262 | biostudies-arrayexpress
Sort   by:  
 Page size