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ProteomicsCoordination of fungal biofilm development by extracellular vesicle cargo
The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system. The biofilm cells release extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. Here, we define functions for numerous EV cargo proteins in ...
ORGANISM(S): Candida albicans (Yeast) 
2022-02-16 | PXD028596 | Pride
Candida albicans Extracellular vesicles Matrix proteomics Biofilm Biofilms 
ProteomicsCandida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses
Extracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication. Fungal EVs contain numerous factors involved in a diverse array ...
ORGANISM(S): Candida albicans SC5314 
2025-05-26 | PXD045873 | Pride
Candida albicans Biofilm Vesicles 
UnknownHuman Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus.
Not available
S-EPMC7157820 | biostudies-literature
ProteomicsGenetic-based reporter systems for labelling and differentiation of host-derived extracellular vesicles reveal their association with a human-pathogenic fungus
Extracellular vesicles (EVs) have gained attention as a mechanism facilitating intercellular as well as interkingdom communication during host-microbe interactions. Recently we showed that upon infection, host polymorphonuclear leukocytes produce antifungal EVs targeting the clinically important fun...
ORGANISM(S): Homo sapiens (Human) Aspergillus fumigatus CEA17 
2024-11-13 | PXD050398 | Pride
Green fluorescent protein Aspergillus fumigatus A549 epithelial cells Cd9 Extracellular vesicles Cd81 Cd63 Nanoluciferase 
ProteomicsAspergillus fumigatus melanin manipulates the cargo and kinetics of neutrophil-derived extracellular vesicles
Neutrophil-derived extracellular vesicles have regained scientific interest as potent ‘wireless’ modulators with pleiotropic effects on the immune system. A few studies have addressed their role in the context of microbial pathogenesis showing their bacteriostatic effects against Staphylococcus aure...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2019-05-17 | PXD005994 | Pride
Antifungal extracellular vesicles Aspergillus fumigatus Melanin Neutrophils 
ProteomicsCandida non-albicans biofilm-derived extracellular vesicles
Currently, non-albicans Candida species, including C. tropicalis, C. glabrata and C. parapsilosis, are becoming an increasing epidemiological threat, predominantly due to the distinct collection of virulence mechanisms, as well as emerging resistance to the antifungal drugs typically used in the tre...
ORGANISM(S): [Candida] glabrata CBS 138 
2022-06-23 | PXD033327 | Pride
Extracellular vesicles Pathogenic fungi Candida Biofilm 
ProteomicsAntifungal turbinmicin alters functional vesicle cargo
Extracellular vesicle delivery in Candida biofilms is important for matrix delivery and associated drug-resistance. Prior study found the antifungal turbinmicin inhibits vesicle release. We find the antifungal turbinmicin inhibits both vesicle release as well as cargo loading. Using comparative vesi...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-06 | PXD076431 | Pride
Turbinmicin Proteomics Candida Extracellular vesicles 
UnknownPlant Roots Release Small Extracellular Vesicles with Antifungal Activity.
Not available
S-EPMC7765200 | biostudies-literature
ProteomicsCandida non-albicans biofilm-derived vesicles
Currently, non-albicans Candida species, including C. tropicalis, C. glabrata and C. parapsilosis, are becoming an increasing epidemiological threat, predominantly due to the distinct collection of virulence mechanisms, as well as emerging resistance to the antifungal drugs typically used in the tre...
ORGANISM(S): Candida tropicalis MYA-3404 
2022-06-23 | PXD033300 | Pride
Extracellular vesicles Pathogenic fungi Candida Biofilm 
ProteomicsFunctional properties of Candida albicans extracellular vesicles released in the presence of the antifungal drugs amphotericin B, fluconazole and caspofungin
Identification of proteins contained in extracellular vesicles of Candida albicans 10231 released in the presence of the antifungal drugs amphotericin B (AMB), fluconazole (FLU) and caspofungin (CASP). We acknowledge the Proteomics and Mass Spectrometry Core Facility of the Malopolska Centre of Biot...
ORGANISM(S): Candida albicans (Yeast) 
2025-06-06 | PXD054683 | Pride
Candida albicans Caspofungin Candidiasis Host response Amphotericin b Fluconazole 
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