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ProteomicsFormation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry
Tissue morphogenesis requires the spatial control over actomyosin contractility to drive cell shape changes. How developmental patterning information controls cell mechanics is poorly understood. In the Drosophila embryo ectoderm, Myosin-II is enriched at the interface between antero-posterior neigh...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-22 | PXD017895 | Pride
Lc-msms Cirl Myo-ii Lrr Drosophila Planar polarity Toll-8 Gpcr 
ProteomicsDual protein kinase/ nucleoside kinase modulat ors for rationally designed polypharmacology
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. A reverse proteomic approach has identified the target responsible for this sensitisation: the deoxycytidine kinase (dCK). Masitinib, as well as o...
ORGANISM(S): Homo sapiens (Human) 
2017-11-13 | PXD007765 | Pride
Human Ltq-velos-orbitrap Labelfree 
ProteomicsA survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling
A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation contro...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD009659 | Pride
Human Lc-msms Cell polarity Pdz Epithelia Death receptor Cell death 
ProteomicsECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and the lack of specific signature makes difficult the development of targeted therapeutic strategy. We previously found that PRICKLE1, an evolutionary conserved protein acting as a regulator of vertebrate development,...
ORGANISM(S): Homo sapiens (Human) 
2019-10-15 | PXD011253 | Pride
Lc-msms Therapeutic targets Triple negative breast cancer Signaling Interactome Prickle1 Ect2 
ProteomicsADAMTSL5 is an epigenetically activated oncogene conferring tumorigenic properties in hepatocellular carcinoma
The remarkable molecular heterogeneity in hepatocellular carcinoma (HCC) continues to challenge development of effective treatments and biomarkers. Here we report that the gene encoding a secreted glycoprotein, ADAMTSL5, is overexpressed and displays hypermethylated CpG islands in its gene body regi...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-17 | PXD016634 | Pride
Lc-msms Hepatocellular carcinoma  oncogene  receptor tyrosine kinase  extracellular matrix  proteoglycans . Damtsl5  hepatocellular carcinoma Secretome 
ProteomicsHSP27 Functional Switch Drives Castration-Resistant Prostate Cancer via mTOR Pathway Activation, Highlighting Promising Combination Therapies to Restore Treatment Sensitivity
Heat shock protein 27 (HSP27) is a multifunctional protein that plays pivotal roles in prostate cancer (PC) progression to a castration-resistant state, known as CRPC. In this study, we identified and analyzed HSP27-protein interaction maps across various prostatic cell models recapitulating differe...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD056858 | Pride
Ap-ms Lc-msms Castration resistant prostate cancer (crpc) Hsp27 Mtor pathway Interactome 
ProteomicsSyntenin inhibition impairs stroma-tumor communication in Multiple Myeloma and improves Bortezomib treatment efficiency
In multiple myeloma, the objective is to assess the impact of syntenin knockout on the secretory profile of bone marrow stromal cells using the HS-5 model.
ORGANISM(S): Homo sapiens (Human) 
2025-07-26 | PXD064458 | Pride
Lc-msms Multiple myeloma Tumor stroma communication Syntenin inhibition Secretome 
ProteomicsCyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by Erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, including clarithromycin (CLR) and azithromycin (AZM), represent the current corn...
ORGANISM(S): Mycobacterium abscessus Bacteria 
2024-12-05 | PXD055560 | Pride
Lc-msms Resistance Macrolide Synergy testing Erm(41) Drug susceptibility Mycobacterium abscessus 
ProteomicsE-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer
E-cadherin is known as an epithelial marker often associated with tumour suppressive function. However, several studies revealed that some tumours cells, such as pancreatic cancer cells, with epithelial traits and high E-cadherin expression can undergo metastasis and form secondary tumours. These ob...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD021795 | Pride
Human Lc-msms E-cadherin Cell invasion Invadopodia Pancreatic cancer 
ProteomicsOxadiazolone derivatives block Staphylococcus aureus growth and biofilm formation by covalently binding to strategic (Ser/Cys)-based enzymes
Staphylococcus aureus is a Gram-positive opportunistic pathogen and a top-priority bacterium in the fight against antimicrobial resistance. Its high propensity to mutate, develop resistance, and become more virulent, as well as its ability to form biofilms, results in difficult-to-treat infections a...
ORGANISM(S): Staphylococcus aureus 
2026-04-01 | PXD073012 | Pride
Lc-msms Dia Gram-positive bacteria  antibiotic resistance  antibiofilm activity  activity-based protein profiling  fabh 
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