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TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
ProteomicsDCLK1 small extracellular vesicle proteome
Doublecortin-like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric cancer. Here we show that DCLK1 expression in the gastric cancer cell line MKN1 impacts EV biogenesis both quantitatively ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD021371 | Pride
Exosomes Proteomics Extracellular vesicles Migration Dclk1 
ProteomicsUnstable Atherosclerotic Plaque Proteome
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, is a major health burden worldwide. Limited understanding as to the molecular drivers of plaque instability and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Utilisin...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD030857 | Pride
Atherosclerosis Therapeutic Mouse Plaque Proteome 
ProteomicsInvadopodia small extracellular vesicles glioblastoma
The therapeutic efficacy of radiotherapy and chemotherapy with temozolomide (TMZ) for glioblastoma (GBM) is currently limited by the augmented invasive abilities of GBM cells that survive treatment, however the underlying mechanisms remain poorly understood. Due to their ability of transporting onco...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD031077 | Pride
Therapeutic Glioblastoma Cancer Small extracellular vesicles Invadopodia Radiotherapy 
ProteomicsCardiomyocytes regulate cardiac fibroblast activation and oxidative stress via CK2 signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGFβ induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, with dy...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD038854 | Pride
Cardiac fibroblasts Cardiomyocytes Proteomics Ck2 Signaling 
ProteomicsMulti-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, are a major health concern worldwide. Limited understanding as to the molecular drivers of plaque destabilisation and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Us...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-24 | PXD018224 | Pride
Atherosclerosis Mouse Plaque Thrombosis 
ProteomicsCardiac Hypertensive-Cmpd17b (therapeutic)
Formyl peptide receptors (FPR) play a critical role in the regulation of resolution of inflammation, an important mediator of hypertension-induced cardiac damage. We have previously discovered an FPR small-molecule prototype Cmpd17b exhibit cardioprotective effects against acute and severe cardiac i...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-23 | PXD035034 | Pride
Heart Therapeutic Proteomics Remodelling Function 
ProteomicsHuman plasma small extracellular vesicle proteome (disease, non-disease)
Human plasma (from both healthy donors and disease) were isolated as described using Norgen plasma/serum exosome purification mini kit, and albumin depleted (HSA depletion kit, Thermo Fisher). Here we show that psEV (plasma small extracellular vesicles) are distinct in their proteome, psEV are biolo...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD021856 | Pride
Human Small extracellular vesicles Plasma Proteome 
ProteomicsFunctional nanovesicles from human trophectodermal cells for embryo implantation
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth critical for successful implantation. While EVs have garnered immense interest in their therapeutic potential in assisted reproductive technology by improving implantation success, their large-scale generation re...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD038856 | Pride
Proteomics Extrusion Nanovesicles Extracellular vesicles Embryo implantation Endometrial receptivity 
ProteomicsHelicobacter pylori outer membrane vesicle proteome
Gram negative bacteria release outer membrane vesicles (OMVs) as part of their natural growth. These OMVs take part in a biological functions including bacterial communication, exchange of genetic material and bacterial pathogenesis. However, the relationship between bacterial growth stage and OMV p...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2021-03-23 | PXD024918 | Pride
Helicobacter pylori Bacteria Proteome Outer membrane vesicle 
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