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ProteomicsSuppression of the E. coli rnpA49 conditionally lethal phenotype via different compensatory mutations
RNase P is an essential enzyme found across all domains of life that is responsible for the 5’-end maturation of precursor tRNA transcripts. Since its discovery in the 1970s, numerous studies have sought to elucidate the mechanisms and biochemistry governing RNase P function. However, much remains u...
ORGANISM(S): Escherichia coli 
2024-05-15 | PXD047498 | Pride
Rnase p Rnase r Lon Suppressor mutation Gene amplification Temperature-sensitivity 
ProteomicsIschemic preconditioning predominantly affects phosphosites involved in myocardial contraction and promotes myocardial stunning while reducing infarction size in rats.
Background: Ischemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after myocardial ischemia that recovers without causing pe...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-15 | PXD050441 | Pride
Myocardial infarction Phosphoproteomics Ischemic preconditioning Echocardiography Speckle tracking analysis Myocardial stunning 
ProteomicsDetoxified synthetic bacterial membrane vesicles as a platform of vaccines against bacteria and SARS-CoV-2
The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop sy...
ORGANISM(S): Pseudomonas aeruginosa 
2023-07-20 | PXD033690 | Pride
Vaccine delivery Label-free proteomics Synthetic bacterial vesicles Outer membrane vesicles (omv) 
ProteomicsPatient-derived scaffolds uncover breast cancer promoting properties of the microenvironment
Tumor cells interact with the microenvironment that specifically supports and promotes tumor development. Key components in the tumor environment have been linked to various aggressive cancer features and can further influence the presence of subpopulations of cancer cells with specific functions, i...
ORGANISM(S): Homo sapiens (Human) 
2020-06-25 | PXD018367 | Pride
Differentiation Cancer stem cells Breast cancer Infiltration Malignancy Scaffold 
ProteomicsLong-term effects on the transcriptome and proteome in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure
Background. Radioiodide 131I is commonly used to treat thyroid cancer and hyperthyroidism, and 131I releases during nuclear accidents have resulted in increased incidence of thyroid cancer in children. To develop a better understanding of underlying cellular mechanisms behind 131I exposure and iden...
ORGANISM(S): Rattus rattus (Black rat) Rattus norvegicus (Rat) 
2020-12-07 | PXD017715 | Pride
Cancer Thyroid Radioiodide 131i treatment Rat Plasma Lc-ms/ms 
ProteomicsMolecular profiling of driver events in metastatic uveal melanoma
Uveal melanoma (UM) is a rare form of melanoma with a genetics and immunology that is different from skin melanoma. Previous studies have identified genetic driver events of early stage disease when the tumor is confined to the eye. In this study, we have characterized genomic events in UM metastase...
ORGANISM(S): Homo sapiens (Human) 
2020-03-18 | PXD017743 | Pride
Bap1 Uveal melanoma Metastasis 
ProteomicsEvaluation of Acute and Subacute Toxicity of Plant Cell Cultures of Scurvy Grass (Cochlearia danica) and Rowan (Sorbus aucuparia) as Food by Oral Administration in Mice
Plant cell culture (PCC) technology is currently being developed to produce plant foods partially decoupled from traditional agriculture practices. By now, the safety of the ingredients produced by PCC technology for food or nutritional purposes has to be tested. Therefore, the objective of this stu...
ORGANISM(S): Cochlearia danica Sorbus aucuparia 
2025-11-10 | PXD065550 | Pride
Plant cell cultures  acute toxicity  subacute toxicity  safety  cochlearia danica  sorbus aucuparia 
ProteomicsALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
High-risk neuroblastoma (NB) currently presents significant clinical challenges. MYCN and ALK, which are often involved in high-risk NB, lead to increased replication stress in cancer cells, providing options for therapeutic exploitation. We previously identified an ATR/ALK inhibitor combination as ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-13 | PXD041824 | Pride
Alk Atr Elimusertib Neuroblastoma Lorlatinib Alkal Ddr Ceralasertib 
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