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ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-05 | PXD020395 | Pride
Heart development  phosphoproteomics  silac  mitochondria  perm1  lipid metabolism 
ProteomicsThe MICOS-MIB complex member PERM1 connects mitochondria with the sarcolemma via ankyrin B
Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profili...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-16 | PXD025745 | Pride
Mitochondria  skeletal muscle  perm1  proteomics 
ProteomicsOrgan protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
Therapeutic strategies to treat acute kidney injury (AKI) are lacking. Preconditioning by hypoxia (HP) and caloric restriction (CR) is highly protective in rodent AKI models. The underlying molecular mechanisms are unknown. A comparative transcriptome analysis after HP and CR identified Kynureninase...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD038328 | Pride
Kynu Hypoxia Caloric restriction Acute kidney injury Kynureninase Nad+ 
ProteomicsFGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Mitochondrial integrated stress response emerged as a major adaptive pathway to respiratory chain deficiency, but tissue-specifics of its regulation or how it adapts to different levels of mitochondrial dysfunction are largely unknown. Here we report that diverse levels of mitochondrial cardiomyopat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-27 | PXD031324 | Pride
Mitochondria Fgf21 Oxphos Cardiomyopathy Clpp 
ProteomicsMitochondria regulate dietary lipid processing in enterocytes
Digested dietary fats are taken up, processed and transported by enterocytes to supply the body with lipids. Most absorbed lipids are assembled into pre-chylomicrons in the endoplasmic reticulum (ER) of enterocytes, which are then transported to the Golgi for maturation and subsequent secretion to t...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-21 | PXD026934 | Pride
Golgi Lipid metabolism Mitochondria Small intestine Enterocyctes Dars2 Er 
ProteomicsLow kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist mainly of densely packed podosomes tightly inter-connected by actin fibers. Their formation requires the presence of the hematopoietic integrin reg...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD026711 | Pride
Sealing zone Podosome Osteoclast Bone resorption Kindlin-3 Integrin 
ProteomicsHighly contractile 3D tissue engineered skeletal muscles from human iPSCs reveal similarities with primary myoblast-derived tissues
Skeletal muscle research is transitioning towards 3D tissue engineered in vitro models reproducing muscle’s native architecture and supporting measurement of functionality. Human induced pluripotent stem cells (hiPSCs) offer high yields of cells for differentiation. It has been difficult to differen...
ORGANISM(S): Homo sapiens (Human) 
2023-10-02 | PXD045145 | Pride
Myongeic differentiation Hipsc 3d tissue 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
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