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ProteomicsTop-Down proteomics of unfractionated Bovine heart mitochondria
Top-Down proteomics pilot experiment of unfractionated Bovine Heart Mitochondria (BHM) using ultra high resolution Q-ToF tandem mass spectrometry (maXis 4G ETD, Bruker Daltonics).
ORGANISM(S): Bos taurus (Bovine) 
2018-04-05 | PXD005350 | Pride
Bovine Mitochondrion Protein Intact Top-down proteomics 
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14245 | MetaboLights
Proteomics2D Spatial Proteomic Mapping Shows Distinct Regional Differences in the Bovine Cardiac Proteome
This study highlights that organs can have variable sub-proteomes that do not necessarily correspond to anatomical features. The bovine heart as a model demonstrates at least 3-5 separate proteomes exist within a 2D plane of the heart. The main differences between these proteomes were the biochemica...
ORGANISM(S): Bos taurus (Bovine) 
2024-10-17 | PXD013375 | Pride
Heart Desmoglein 2 Proteomics Bovine Mitochondria Proteome 
ProteomicsThe inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex
The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein called IF1, but bovine IF1 has no effect on the synthetic activity of the bovine enzyme in mitochondrial vesicles in the presence of a proton motive force. As part of an investigation into the inhibitory eff...
ORGANISM(S): Bos taurus (Bovine) 
2024-01-29 | PXD045079 | Pride
Bovine mitochondria Atp synthase If1 protein Absolute quantification 
ProteomicsMitochondrial Protein Hyperacetylation in the Failing Heart
Mitochondrial proteomics was used to identify energy metabolic derangements that occur during the early stages of heart failure in well-defined mouse models. Levels of β-hydroxybutyrate dehydrogenase 1 (BDH1), a key enzyme in ketone oxidation, was upregulated. 13C-substrate flux studies and metabol...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-26 | PXD001652 | Pride
Heart failure Acetylation Mitochondria 
ProteomicsMolecular characterization of a complex of Apoptosis Inducing Factor 1 (AIFM1) with cytochrome c oxidase of the mitochondrial respiratory chain
Combining mass spectrometry based chemical cross-linking and complexome profiling, we analyzed the interactome of heart mitochondria. We focused on complexes of oxidative phosphorylation and found that dimeric apoptosis inducing factor 1 (AIFM1) forms a defined complex with ~10% of monomeric cytochr...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD025102 | Pride
Structural docking Cox Aifm1 Xl-ms Bovine heart mitochondria 
ProteomicsMRPS36 provides a missing link in the eukaryotic 2-oxoglutarate dehydrogenase complex for recruitment of E3 to the E2 core - Phospoproteomics data
The tricarboxylic acid (TCA) cycle, or Krebs cycle, is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. The enzymes involved in this cycle generate the reducing equivalents NADH and FADH2 by a series of enzymati...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036896 | Pride
2-oxoglutarate dehydrogenase (ogdhc)  mrps36  tricarboxylic acid (tca) cycle  krebs cycle  heart mitochondria  cross-linking mass spectrometry  complexome profiling  structural biology  comparative genomics 
ProteomicsHigher dimensional cross-linking with a tetra-reactive cross-linker
A tetrameric CID-cleavable cross-linker was synthesized and applied to BSA and isolated mitochondria from mouse hearts. A real-time instrument method was developed to dynamically target released peptides from cross-linked species, enabling their characterization through a series of ms3 scans.
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-11-27 | PXD032222 | Pride
Mitochondria Cross-linking 
MetabolomicsMetabolic alterations caused by the mutation and overexpression of the Tmem135 gene
Mitochondria are highly dynamic organelles undergoing fusion, fission and degradation. Although mitochondria are known to be essential for cellular metabolism, it is not fully understood how mitochondrial dynamics affect cellular metabolism. We previously identified a mouse gene, transmembrane prote...
2021-02-12 | MTBLS1410 | MetaboLights
UnknownIdentification of unusual phospholipids from bovine heart mitochondria by HPLC-MS/MS.
Not available
S-EPMC7707168 | biostudies-literature
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