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ProteomicsQuantitative Secretome Analysis of Activated Jurkat Cells
A quantitative label-free secretome analysis protocol using a click chemistry-based approach for the enrichment of secreted glycoproteins was adapted for and applied to a T cell model. There, Jurkat cells were activated via PMA/ionomycin and the dynamic modulation of the T cell secretome was investi...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004280 | Pride
T cell model Jurkat Quantitative label-free lc-ms/ms Secretome 
ProteomicsComparative proteome and serum analysis identified FSCN1 as a marker of abiraterone resistance in castration-resistant prostate cancer
Background: Abiraterone (Abi) is an androgen receptor signaling inhibitor that significantly improves patients' life expectancy in metastatic prostate cancer (PCa). Despite its beneficial effects, many patients have baseline or acquired resistance against Abi. Objective: To identify predictive seru...
ORGANISM(S): Homo sapiens (Human) 
2023-08-28 | PXD038697 | Pride
Abiraterone Fscn1 Prostate cancer Amacr Ctag1a Biomarker Klk2 
ProteomicsHepatocyte-specific BIRC5 (Survivin)-knockout-mouse model, Subcellular fractionation
Experimental design For the label-free proteome analysis 17 mice were used composed of 5 individual wildtype mice for each condition before (WTprePHE) and after hepatectomy (WTpostPHE). For the pre-hepatectomy condition four BIRC5-knockout mice (KOprePHE) were analyzed and three individuals after p...
ORGANISM(S): Mus musculus (Mouse) 
2014-05-22 | PXD000625 | Pride
Liver regeneration Birc5 Knockout Mouse Survivin Liver 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026876 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026913 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsPlasma proteomics enable differentiation of lung adenocarcinoma from chronic obstructive pulmonary disease (COPD)
Background: Chronic obstructive pulmonary disease (COPD) is a major risk factor for the development of lung adenocarcinoma (AC). AC often develops on underlying COPD, thus the differentiation of both entities by biomarker is challenging. Although survival of AC patients strongly depends on early dia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-17 | PXD035120 | Pride
Machine learning Random forest Serpina3 Saa1 Chronic obstructive pulmonary disease Artificial intelligence Adenocarcinoma of the lung Plasma proteomics 
ProteomicsDifferential interferon-α subtype immune signatures suppress SARS-CoV-2 infection
Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies and have been successfully employed for the treatment of viral diseases. Humans express twelve IFN-alpha (α) subtypes, which activate downstream signall...
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD026079 | Pride
Isg Sars-cov-2 Antiviral treatment Therapy Covid-19 Type i ifn Ifnα subtypes 
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion mutagenesis...
ORGANISM(S): Cytomegalovirus Rat cytomegalovirus ALL-03 Rattus norvegicus (Rat) 
2022-12-09 | PXD033639 | Pride
Interferon  ubiquitin-proteasome system  cullin-ring ubiquitin ligases (crl)  ddb1  dcafs  viral dcaf (vdcaf)  antiviral  cytomegalovirus (cmv)  stat2  irf9   
ProteomicsProteome profiling of enzalutamide-resistant cell lines and serum analysis identified ALCAM as marker of resistance in castration-resistant prostate cancer
Enzalutamide (ENZA) is a frequently used therapy in metastatic castration-resistant prostate cancer (mCRPC). Baseline or acquired resistance to ENZA have been observed, but the molecular mechanisms of resistance are poorly understood. We aimed to identify proteins involved in ENZA resistance and to...
ORGANISM(S): Homo sapiens (Human) 
2022-06-24 | PXD031847 | Pride
Prostate cancer Secondary resistance Enzalutamide 
ProteomicsMachine learning identifies clinical sepsis phenotypes that translate to the plasma proteome
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
Mass spectrometry Precision medicine Artificial intelligence Plasma Cluster analysis 
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