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ProteomicsCulture and stimulation conditions influence protein expression of primary fibroblasts
Tissue fibrosis is a common pathway to organ injury and failure. It is characterized by an excessive deposition of extracellular matrix (ECM) in organs. Deciphering the fibrogenic processes is of utmost importance, as there are few effective therapies in fibrotic diseases 1. Systemic sclerosis (SSc)...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025374 | Pride
Mass spectrometry Fibrosis Primary fibroblasts Tgf-β1 Systemic sclerosis 
ProteomicsSmall angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody
The antigen binding fragment (Fab) of Mannitou IgM was recombinantly produced in HEK293 FreeStyle cells and purified over a cobalt-affinity chromatography followed by size exclusion chromatography (SEC). Besides the presence of the monomeric Mannitou Fab assembly, existing of the light chain (VL-CL)...
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD057808 | Pride
Igm Glycosylation Maniitou 
ProteomicsLIKE EARLY STARVATION is involved in the regulation of starch initiation in potato (Solanum tuberosum cv. Désirée) tubers
Starch initiation has been intensively investigated. In tubers of Solanum tuberosum, it is controlled by a heteromultimeric isoamylase complex composed of StISA1 and StISA2. Moreover, two non-catalytic starch binding proteins (i.e, ESV1 and LESV) regulate leaf starch metabolism in Arabidopsis. Both ...
ORGANISM(S): Solanum tuberosum (Potato) 
2026-01-26 | PXD055189 | Pride
Starch glucans Proteomics Solanum tuberosum Esv1 Lesv 
ProteomicsEnhancing ZooMS applications with MALDI-FTICR mass spectrometry on Pleistocene material showing variable collagen preservation
Advances in high-throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have addressed the issue of intense skeletal fragmentation at Palaeolithic archaeological sites, which hinders morphological identification. However, the challenge of variable...
ORGANISM(S): Bos taurus (Bovine) Rangifer tarandus (Reindeer) (Cervus tarandus) 
2025-03-17 | PXD056898 | Pride
Lc-msms Paleoproteomics Prm Casi Zooms Maldi-ms Collagen 
ProteomicsRobust high throughput proteomics identification and deami-dation quantitation of extinct species up to Pleistocene with Ultrahigh Resolution MALDI-FTICR Mass Spectrometry
Peptide mass fingerprinting (PMF) using MALDI-TOF mass spectrometry allows the identification of bone species based on their type I collagen sequence. In archaeological or paleontological field, PMF is known as ZooMS and is widely implement-ed to find markers for most species, including the extinct ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Rhinoceros Castor fiber (Eurasian beaver) Cervus Equus caballus (Horse) 
2023-04-28 | PXD038283 | Pride
Species identification Deamidation High-throughput Paleoproteomics Maldi-fticr 
ProteomicsInfection of RAW 264.7 cells by Murine Leukemia Virus-derived retroviral pseudotype expressing the envelope glycoprotein of EBOV is enhanced by immune serum and monoclonal antibodies
It has been shown that antibodies can enhance Ebola virus (EBOV) infection at sub-neutralizing concentrations. The effect of antibodies on the infection of murine cell line (RAW 264.7) with MLV-EBOV, a murine leukemia virus pseudotype expressing surface glycoprotein (GP) of EBOV and green fluorescen...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-26 | PXD066513 | Pride
Virus Monoclonal antibodies Proteomic Ebola Epitope 
ProteomicsPGPR isolated from the rhizosphere of a wheat ancestor and active in an elite cultivar: metabolomics and proteomics of bacterial exudates affecting root development
Two diazotrophic bacteria, BPMP-PU-28 and BPMP-EL-40, isolated from the rhizosphere of a wild wheat ancestor (T. t. dicoccoides) grown in soil from its refuge area in the Fertile Crescent or from south of France, respectively, were shown to behave as efficient Plant Growth Promoting Rhizobacteria (P...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-03-08 | PXD034914 | Pride
Proteomics Metabolomics Bacterial exudate Plant-microbiota communication Pgpr Diazotroph Durum wheat Domestication 
ProteomicsGlycated bovine serum albumin for use in animal models – in vitro methodology and characterization of a glycated substrate for feeding trials
Advanced Glycation End-Products (AGEs) are a heterogeneous group of compounds resulting from the non-enzymatic condensation between reducing sugars and amino groups, primarily lysine and arginine moieties (Perrone et al., 2020). The in vivo glycation of proteins is part of normal metabolism, but pat...
ORGANISM(S): Bos taurus (Bovine) 
2023-07-06 | PXD041212 | Pride
Carboxymethyllysine Glycation Proteomics Mass spectrometry Glyoxal Bsa 
ProteomicsO-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in hepatic stellate cells
Liver injury causes “transdifferentiation” of quiescent hepatic stellate cells (Q-HSCs) into wound repairing myofibroblasts (MF-HSCs), whose uncontrolled activation leads ultimately to liver fibrosis. Although this process is triggered by deep metabolic and transcriptional reprogramming, functional ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD045860 | Pride
Fibrogenic liver injuries Human O-linked β d n acetylglucosaminylation 
ProteomicsTaxonomic identification and sex determination of Bos and Bison teeth using low-invasive high-resolution mass spectrometry
Differentiating between the genus Bos and Bison from fossil bones and teeth can be difficult and even impossible due to taphonomic deterioration, which can also muddle the identification of the sex of the animal. Both are key issues for palaeobiological and palaeoecological studies, as the two speci...
ORGANISM(S): Bos taurus (Bovine) Bison bonasus Bison bison bison Bos primigenius 
2025-06-16 | PXD063063 | Pride
Bison Tooth Bos Palaeoproteomics Large bovids Enamel Genus identification Sexing 
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