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ProteomicsNaive and DSS Murine Colon TMTpro bRP fractionation N-terminomics
The mammalian lysosomal protease legumain is often dysregulated in pathophysiological conditions including inflammation, neurodegeneration, and cancer, yet its proteolytic targets are poorly defined. To profile protease substrates degradomics techniques typically employ enrichment strategies to sele...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060852 | Pride
Mouse Protease Fractionation Legumain N-terminomics Colon Colitis 
UnknownEmploying complementary fractionation-based N-terminomics approaches enhances the identification of legumain cleavage events in naive and inflamed colon tissue.
Not available
S-EPMC12447244 | biostudies-literature
ProteomicsMurine colon HUNTER N-terminomics
The mammalian lysosomal protease legumain is often dysregulated in pathophysiological conditions including inflammation, neurodegeneration, and cancer, yet its proteolytic targets are poorly defined. To profile protease substrates degradomics techniques typically employ enrichment strategies to sele...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060854 | Pride
Legumain Mouse Colon Colitis Hunter 
ProteomicsActive zone plasticity drives presynaptic dephosphorylation in Drosophila
The function of the nervous system relies on tightly regulated, yet plastic synaptic vesicle release machinery at the presynaptic active zone. In Drosophila, a form of presynaptic active zone plasticity, Presynaptic Scaling, or PreScale, is executed by the ELKS-family scaffold protein Bruchpilot (BR...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-06-09 | PXD067034 | Pride
Bruchpilot (brp) Phospho-proteomics Drosophila Presynaptic scaling Prescale Proteomics 
ProteomicsAn Integrated Workflow for Analysis of Multiple Protein Post-Translational Modifications
Investigating multiple protein post-translational modifications (PTMs) is critical for unraveling the complexities of protein regulation and the dynamic interplay among PTMs, a growing focus in proteomics. However, simultaneous analysis of diverse PTMs remains a significant technical challenge, as e...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-02-16 | PXD061601 | Pride
Lc-ms/ms Dia Tmt Ptm Pdx Dda 
ProteomicsShotgun analysis of proteins in NDUFA11 KO and WT HEK 293T cells.
The effect of the depletion of an ETC complex I protein component - NDUFA11 on the proteome in HEK 293T cells was studied. TMT-based relative quantification of protein levels were performed in NDUFA11 KO vs WT cells and in NDUFA11 KO vs WT cells that expressed an EGFP-MAPT (Tau protein) construct. I...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD038397 | Pride
Ndufa11 ko Egfp-mapt expression Etc complex i Hek 293t 
ProteomicsCytosolic N6AMT1-dependent translation supports mitochondrial RNA processing to prevent double-stranded RNA accumulation
Mitochondrial biogenesis relies on both the nuclear and the mitochondrial genomes, and the mechanisms that support their coordinated expression are not fully understood. Improper mitochondrial DNA expression can lead to inborn error of metabolism, inflammation, and aging. Here, we investigate N6AMT1...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD051311 | Pride
Innate immunity Rna processing Mitochondria Oxphos Mitochondrial disease Translation 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative K562 proteomics
Mitochondrial disorders (MDs) are among the most common inborn errors of metabolism and primarily arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060163 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative patient LCL proteomics
arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Here, we build on previous efforts to discover genes necessary for OXPHOS and report a highly complem...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060152 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - sgNUDT5 proteomics
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060320 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
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