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ProteomicsA First-Trimester Serum Proteomic Signature for Early Predic-tion of Preeclampsia: Integrated Untargeted and Targeted Mass Spectrometry with Machine Learning
First-trimester prediction of preeclampsia (PE) remains a major clinical challenge, par-ticularly outside specialized fetal medicine centers. This study aimed to identify and validate serum protein biomarkers for early PE prediction using an integrated proteo-mic approach. A prospective cohort of 64...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD080843 | Pride
Preeclampsia  first-trimester screening  serum proteomics  prognosis  dia-ms  mrm-ms  machine learning  biomarkers  complement system  mass spectrometry. 
ProteomicsThe Parallel Reaction Monitoring-Parallel Accumulation Serial Fragmentation (prm-PASEF) Approach for Multiplexed Absolute Quantitation of Proteins in Human Plasma
In the study reported here, a prm-PASEF approach was used for multiplexed absolute quantitation of proteins in human plasma using isotope-labeled peptide standards for 125 plasma proteins, over a broad (104–106) dynamic range. Optimization of LC and MS parameters, such as accumulation time and coll...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD028279 | Pride
Proteomics Prm Mrm Timstof Srm Ion mobility 
ProteomicsProteome profiling of the exhaled breath condensate after long-term spaceflights
Abstract: The aim of the study was to analyze exhaled breath condensate (EBC) proteome changes due to the effects of spaceflight factors. All the protocols were approved at the Institute of Biomedical Problems – Russian Federation State Scientific Research Center in the frame of «Protocon» experimen...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD014191 | Pride
Exhaled breath condensate Ebc 
ProteomicsPROTEOMIC CHARACTERIZATION OF DRY BLOOD SPOTS OF HEALTHY WOMEN DURING SIMULATION THE MICROGRAVITY EFFECTS USING DRY IMMERSION
This study is unique in that it was the first time that it was the female response to microgravity simulated by 3-day dry immersion that was analyzed. The result of the choice of the object of research fell on dry blood spots, since the technique of capillary blood sampling is less invasive and allo...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027654 | Pride
Human Healty human Mass-spectrometry Label-free Dry immersion 
ProteomicsTHE EFFECTS OF SPACE FLIGHT FACTORS ON THE HUMAN PLASMA PROTEOME, INCLUDING BOTH REAL SPACE MISSIONS AND GROUND-BASED MODEL EXPERIMENTS.
The aim of the study was to continue of the proteomic data accumulation on the effects of space flight factors on the human body, including ground-based model experiments. Blood plasma samples were collected from 5 healthy men included in the 21 days head-down bed rest experiment (HDBR) and 5 volun...
ORGANISM(S): Homo sapiens (Human) 
2019-07-04 | PXD013305 | Pride
Spaceflight Ground-base experiments Proteomics Mass-spectrometry Astronauts Dry immersion Head down bed rest Extreme conditions 
ProteomicsLC-MSMSMass Spectrometric detection of SARS-CoV-2 virus in scrapings of the epithelium of the nasopharynx of infected patients via Nucleocapsid N protein
Detection of viral RNA by PCR is currently the main diagnostic tool for COVID-191. The PCR-based test, however, shows limited sensitivity, especially at early and late stages of the disease development, and is relatively time consuming. Fast and reliable complementary methods for detecting the viral...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2020-08-14 | PXD019648 | Pride
Covid Covid-19 Proteomics Sars-cov-2 
ProteomicsComparative analysis of CVF proteome composition during neoplastic transformation of cervix among females of reproductive age
The aim of this study is characterization of proteomic composition of the CVF for assessing the severity of HPV-associated intraepithelial neoplasias of the cervix among women of reproductive age.
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD011472 | Pride
Lc-ms/ms Hpv Cervical cancer Cvf 
ProteomicsAssessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition, including markers sST2, NT-proBNP and D-dimer
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 2...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD043604 | Pride
Head-down bed rest Mass spectrometry Nt-probnp D-dimer Sst2 
ProteomicsThe secretome of cultured human endothelial cells in modelled microgravity
Using chromatography-mass spectrometry on an Ultimate 3000 chromatograph combined with a Maxis 4G mass spectrometer, the secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and modeling microgravity for 24 hours was studied. In the secretome of cells under mi...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD013497 | Pride
Endothelial cells Microtubules Rho-gtpases Secretome Chromatography-mass spectrometry 
ProteomicsAssessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 2...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD053149 | Pride
Head-down bed rest Mass spectrometry Blood Retinol-binding protein Cardiovascular system 
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