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OtherLysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.
Data from ProteomeXchange: PXD ID: PXD001114. Experiment: LysargiNase, silac, file: LR_Ulilysin_PMA_A1_121126.mzml. Published as part of . From the Abstract: {{i}} To improve proteome coverage and protein C-terminal identification, we characterized the Methanosarcina acetivorans thermophilic protei...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310005457 | GPMDB
Resource Reanalysis 
ProteomicsInvestigating N-terminal shedding of GPR125 in GPR125 overexpressing HEK293T cells using N- and C-terminal enrichment and different cleavage strategies
The study was conducted to elucidate potential cleavage sites of GPR125 which are known to undergo N-terminal shedding through autoproteolysis in a region different to other GRPs. To do these different enzymatic strategies as well as enrichment of both N-terminal and C-terminal peptides, was conduct...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD083139 | Pride
Gpr125 Scx C-terminal Lysate Hek293t Enrichment Lc-msms Adra3 N-terminal Medium 
TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 – CTAP discovery
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. CTAPs can arise from internal protein cleavage events during which the N-terminal fragme...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055814 | Pride
C-terminal amide Oxidative stress Ubiquitin ligase Fbxo31 
ProteomicsUbiquitin C-terminal Extension (CxUB) DUB cleavage assay
Ubiquitin is a conserved modifier regulating the stability and function of numerous target proteins. In all eukaryotes, polyubiquitin precursors are generated and processed into ubiquitin monomers. The final ubiquitin unit always contains a C-terminal extension, but its physiological significance i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-09-24 | PXD065783 | Pride
Dubs Cxub Ubiquitination 
ProteomicsPhotoredox-catalyzed decarboxylative C-terminal differentiation for bulk and single molecule proteomics
Methods for the selective labeling of functional groups on peptides are being developed and used in the workflow of both current and emerging proteomics technologies, such as single-molecule fluorosequencing. Photoredox methods in discriminative targeting of the terminal carboxylic acid from the int...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Homo Sapiens (ncbitaxon:9606) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2021-06-01 | MSV000087551 | MassIVE
ProteomicsGenesis and regulation of C-terminal cyclic imides from protein damage
C-Terminal cyclic imides are post-translational modifications (PTMs) that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapt...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD054016 | Pride
Protein cleavage Cyclic imide Cereblon Protein damage Post-translational modifications Deamidation 
ProteomicsA Landscape of Ectodomain Shedding by Quantitative Protein Terminomics
Ectodomain shedding is a proteolytic process that regulates level and function of membrane proteins. By quantitative protein terminomics consisting of N- and C-terminal peptide enrichment, TMT-labeling and mass spectrometry, we quantified protein termini in the cultured media across 10 human cell li...
ORGANISM(S): Homo Sapiens (human) 
2021-03-05 | PXD021378 | JPOST Repository
ProteomicsThe C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent potentially lethal monogenic disorder. Mutations in the PKD1 gene, which encodes polycystin-1 (PC1), account for approximately 78% of cases. PC1 is a large 462-kDa protein that undergoes cleavage in its N and C-terminal domai...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-17 | PXD040210 | Pride
Metabolism Polycystin-1 (pc1) C-terminal tail (ctt) Autosomal dominant polycystic kidney disease (adpkd) Nicotinamide nucleotide transhydrogenase (nnt) Mitochondria 
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