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UnknownSatellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture.
Not available
S-EPMC6141091 | biostudies-literature
ProteomicsQuantitative phosphoproteome of contracting C2 myotubes with pharmacological intervention of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK cascades
Various protein kinases are regulating the intracellular signaling network of skeletal muscle cells. Despite that many of the involved kinases are known, their downstream targets have remained largely unexplored. To deepen our understanding of the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD018667 | Pride
Phosphoproteomics Mouse Akt Rsk S6k Skeletal muscle Lc-ms/ms 
UnknownPancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains.
Not available
S-EPMC11532064 | biostudies-literature
ProteomicsFlnc d18-21/d1-3 pulldown experiments
The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc acts as a signaling adaptor which is phosphorylated at S2234 in its mechanosensitive domain 20 (d20) through AKT. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053236 | Pride
Ap-ms Flnc d18-21 interactome C2 cells/myotubes 
ProteomicsLabel-free global phosphoproteomics experiment using PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK pathway activation and inhibition
The signaling network of skeletal muscle cells is controlled by a variety of protein kinases. Although many kinases are known players, their downstream targets are still largely unexplored. To gain further knowledge about the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling networks in myotubes, ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029678 | Pride
Phosphoproteomics Mouse Akt Rsk Ms S6k Skeletal muscle 
ProteomicsHuman FLNc-S2233/S2236 phosphorylation after EPS treatment (PRM analysis)
The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc acts as a signaling adaptor which is phosphorylated at S2234 in its mechanosensitive domain 20 (d20) through AKT. Her...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053234 | Pride
Phosphoproteomics C2 cells Targeted ms Prm Skyline Mechanical stress 
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Based on the global SILAC and label-free phosphoproteomics experiments, we generated an inclusion list for validation of known and novel AKT, RSK and S6K targets containing the RxRxxp[ST] motif. Samples were analyzed by targeted MS using PRM.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029633 | Pride
Phosphoproteomics Mouse Akt Rsk Targeted ms S6k Skeletal muscle 
ProteomicsPhosphoproteomics of MuSK Signaling
The development of the neuromuscular synapse depends on signaling processes which involve protein phosphorylation as a crucial regulatory event. The receptor tyrosine kinase MuSK is the key signaling molecule at the neuromuscular synapse whose activity is required for the formation of a mature and f...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-05 | PXD000558 | Pride
Phospho Musk Mouse Neuromuscular synapse 
ProteomicsPhosphoproteomics of MuSK Signaling
The development of the neuromuscular synapse depends on signaling processes which involve protein phosphorylation as a crucial regulatory event. The receptor tyrosine kinase MuSK is the key signaling molecule at the neuromuscular synapse whose activity is required for the formation of a mature and f...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-05 | PXD000878 | Pride
Musk Time course Phosphoproteomics Itraq Muscle 
UnknownAntisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells.
Not available
S-EPMC11834094 | biostudies-literature
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