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MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsPosternak_PROTACdegradation_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E. This dataset provides a proteome-wide view of protein degradation after treatment...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-10 | MSV000085271 | MassIVE
ProteomicsPosternak_PROTACagainstBRAFV600E_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-07 | MSV000084551 | MassIVE
ProteomicsGlobal proteomics and metabolomic data of PROTAC in cancer cells
Global proteomics and metabolomic data of PROTAC in cancer cells are deposited here.
ORGANISM(S): Homo Sapiens (human) 
2025-03-13 | PXD061773 | JPOST Repository
ProteomicsGlobal proteomics and metabolomic data of PROTAC in cancer cells
Global proteomics and metabolomic data of PROTAC in cancer cells are deposited here.
ORGANISM(S): Homo Sapiens (human) 
2025-03-13 | PXD061771 | JPOST Repository
ProteomicsThe effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD050260 | Pride
Mlk3 Cep1347-vhl-02 protac Hcc1806 Mcf-7 Mda-mb-468 
ProteomicsGlobal proteomics and metabolomic analysis of PROTAC in cancer cell
The raw data for global proteomics and metabolomic analysis of PROTAC in cancer cell is posted here.
ORGANISM(S): Homo Sapiens (human) 
2025-03-18 | PXD061937 | JPOST Repository
ProteomicsA Triple Action PROTAC for Wild-Type p53 Cancer Therapy
Multiagent chemotherapy remains a cornerstone of cancer treatment but the side effects of each drug component can heighten toxicity and the pharmacologic challenges in achieving simultaneous cellular delivery can reduce efficacy and promote resistance. To address these limitations, we developed a Tr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD060332 | Pride
Bet proteins Cancer Brd4 Taptac Degradation Mdm2/hdm2 Protac Mdmx/mdm4/hdmx Chimera Therapeutic P53 Stapled peptide 
UnknownAminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.
Not available
S-EPMC8187316 | biostudies-literature
ProteomicsMass Spectrometry of T47D cells treated with PTK6 PROTAC
PTK6 PROTAC treatment of T47D breast cancer cells were analyzed with mass spectrometry for determining PTK6 PROTAC specificity and global proteomic changes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095916 | MassIVE
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