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ProteomicsProteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract – a role for antioxidants in skin health
Environmental air pollution such as diesel smoke emission has been shown to have an adverse effect on human skin. Although epidemiological studies showing adverse effects such as oxidative stress-induced aging exists, studies showing the cellular and molecular response to such stress are rare. Using...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD006743 | Pride
Tocopherol Mass spectrometry Quantitative proteomics Skin keratinocytes Pollution 
ProteomicsMining gastric cancer cellular quantitative phosphotyrosine proteomics data to analyse the signiling cascade regulated my CAMKK2 in gastric cancer
Gastric cancer is a global health concern. Tyrosine kinases (TKs) are important mediators of signaling cascades, which regulate diverse biological processes like growth, differentiation, metabolism, and apoptosis in response to external and internal stimuli. Molecular alterations in various signalin...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032001 | Pride
Sto-609 Data mining Camkk2 Mass spectrometry Proteomics Stat3 Gastric cancer 
ProteomicsChronic shisha exposure alters phosphoproteome of oral keratinocytes
Shisha smoking has been epidemiologically linked to development of oral lesions as well as various cancers. However, few molecular studies investigate the pathobiology of shisha induced cancer. In this study we investigate the effects of chronic shisha exposure in an in vitro model using normal, imm...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD011318 | Pride
Oral cancer Hookah Waterpipe tobacco smoking Narghile tobacco Carcinogenesis High-throughput Oscc Orbitrap fusion 
ProteomicsQuantitative proteomic analysis of lung adenocarcinoma and squamous cell carcinoma primary tissues using high resolution mass spectrometry
Lung cancer is the leading cause of preventable death globally and is broadly classified into adenocarcinoma and squamous cell carcinoma depending upon cell type. In this study, we carried out mass spectrometry based quantitative proteomic analysis of lung adenocarcinoma and squamous cell carcinoma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008700 | Pride
Proteomics Lung squamous cell carcinoma Lung adenocarcinoma Itraq labelling 
ProteomicsMining gastric cancer cellular quantitative proteomics data to analyse the proteome change upon CAMKK2 inhibition
Gastric cancer is a global health concern. Molecular alterations in various signaling pathways have been implicated in the development and late-stage progression/metastasis of gastric cancer. Reports have suggested that Wnt signaling pathway might contribute to gastric carcinogenesis by stimulating ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-13 | PXD023423 | Pride
Sto-609 Data mining Camkk2 Mass spectrometry Proteomics Gastric cancer 
ProteomicsPhosphoproteomic analysis reveals cytoskeletal remodelling via CDC42-PAK signaling in lung mucoepidermoid cells upon chronic exposure to cigarette
Despite the fact that smoking is the major cause of lung cancer, there is no clear mechanism detailing how chronic exposure of cigarette smoke alters the global signaling in lung cells. To investigate the altered signaling in lung cells, in this study, we carried out SILAC-based quantitative phospho...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006672 | Pride
Nsclc Smoking In vivo labelling Phosphoproteomics 
ProteomicsCigarette smoke induces mitochondrial metabolic reprogramming in lung cells
Cigarette smoking remains the leading cause of non-small cell lung carcinoma. Studies involving acute exposure of smoke on lung cells revealed induction of pre- cancerous state in lung cells. Recently few studies have reported the chronic effect of cigarette smoke in inducing cellular transformation...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD007108 | Pride
Cigarette smoking Metabolism Mass spectrometry Nsclc 
ProteomicsCalcium/calmodulin dependent protein kinase kinase 2 (CAMKK2), an alternative to curcumin in head and neck squamous cell carcinoma.
Curcumin has been shown to exhibit anti-neoplastic effects. However, due to its poor bioavailability, use of curcumin as an anti-cancer drug is limited. It is thus necessary to identify molecules that could be targeted using anti-cancer agents as alternatives to curcumin. For this, it is important t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD007256 | Pride
Bioavailability Head and neck cancer Mass spectrometry Signaling pathways Kinases Phosphoproteomics Quantitative proteomics 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke in oral keratinocytes
Smoking is the leading cause of preventable death worldwide. It increases the risk for various diseases including respiratory diseases, vascular diseases and different cancers including lung, oral and bladder cancer. Despite being the leading cause of oral cancer, the molecular mechanisms resulting ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-05 | PXD007637 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke and chewing tobacco in oral keratinocytes
Tobacco is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, the molecular mechanisms resulting in malignancy upon tobacco exposure are yet to be fully elucidated. We therefore sought to ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD007127 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
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