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ProteomicsTwo aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein
Aminoacyl-tRNA synthetases (aaRSs) attach amino acids to their cognate transfer RNAs. In eukaryotes, a subset of cytosolic aaRSs is organized into a multi-synthetase complex (MSC), along with specialized scaffolding proteins referred to as aaRS-interacting multifunctional proteins (AIMPs). In Plasmo...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli 
2022-06-09 | PXD033057 | Pride
Aminoacyl-trna synthetase-interacting multifunctional proteins (aimp) Gst-like domain Aminoacyl-trna synthetase Protein complex Trna Rna binding protein Cell surface protein multi-aminoacyl-trna synthetase complex (mars/msc) 
ProteomicsGFP TurboID in Human HCT116 cells
GFP-TurboID samples were generated as controls for several TurboID experiments in Human HCT116 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-12-13 | PXD027122 | Pride
Gfp Qexactive+ Turboid Human Controls 
ProteomicsCLUH interactome reveals its association to SPAG5 and its proximity to the translation of mitochondrial proteins
Mitochondria require thousands of proteins to fulfil their essential function in energy production and other fundamental biological processes. These proteins are mostly encoded by the nuclear genome, translated in the cytoplasm before being imported into the organelle. RNA binding proteins (RBPs) ar...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-12-13 | PXD027158 | Pride
Cluh Turboid Rna binding protein Mitochondrial proteins Bioid 
ProteomicsRsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.
The human opportunistic pathogen Staphylococcus aureus has developed multiple strategies to adapt to various environments, to fight and escape the immune system, to spread and persist in host tissues. It is responsible for numerous diseases ranging from benign skin infections to more serious such as...
ORGANISM(S): Staphylococcus aureus 
2019-11-11 | PXD013225 | Pride
Reuglatory rna Nutritional immunity Staphylococcus aureus Oxidative stress 
ProteomicsDEAD box RNA helicase 5 and 17 are novel host factors for Sindbis virus infection.
The DEAD-box ATP-dependent RNA helicases DDX5 and DDX17 play a role in many aspects of cellular RNA biology, including metabolism, translation, splicing, transcription regulation, ribosome biogenesis, mRNA nuclear export, and miRNA processing. Moreover, both RNA helicases were found to either promot...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044867 | Pride
Sindbis virus Ddx5 Helicase Ddx17 Rna 
ProteomicsCoupling tRNAGly gene redundancy with staphylococcal cell wall integrity, antibiotic susceptibility and virulence potential
Redundancy in the number of tRNA genes which occur across species is poorly understood and, in many cases, remains essentially unexplored. In Staphylococcus aureus, several tRNAGly genes encode isoacceptors that either participate in protein synthesis or cell wall formation, upon aminoacylation by t...
ORGANISM(S): Staphylococcus aureus 
2025-07-21 | PXD059048 | Pride
Genome editing Trna-mediated metabolism regulation Staphylococcus aureus Trna gene redundancy 
ProteomicsHuman DICER helicase domain recruits PKR and dsRNA binding proteins during viral infection
The innate immune response against viruses mainly involves type I interferon (IFN) in mammalian cells. The exact contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the type III ribonuclease DICER can generate viral siRNAs in specific condi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-15 | PXD019093 | Pride
Virus Dicer Alphavirus Helicase Interferon Pkr Rnai 
ProteomicsDefinition of the Dicer-2 interactome during viral infection in Drosophila melanogaster
Although many in vitro studies have helped us understand how Dicer-2 is able to discriminate between different dsRNA substrate termini, much less is known about how this translates to the in vivo recognition of viral dsRNA. Indeed, Dicer-2 associates with several dsRNA-binding proteins (dsRBPs), whi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-15 | PXD038898 | Pride
Innate immunity Antiviral Dicer-2 Drosophila c virus 
ProteomicsSystematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells
In mammals, many germline genes are repressed by epigenetic mechanisms to prevent their illegitimate expression in embryonic and somatic cells. To advance our understanding of the complete mechanisms restricting the expression of germline genes in mammals, we analyzed the chromatin signature of germ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD030666 | Pride
Germline genes Erh Prc1.6 Shfm1 Crispr-cas9 screen Dna methylation Es cells Usp7 
ProteomicsDetermination of dsRNA interactome upon Sindbis virus infection in human cells identifies SFPQ as a critical proviral factor
Viruses are obligate intracellular parasites, which depend on the host cellular machineries to replicate their genome and complete their infectious cycle. Long double stranded (ds)RNA is a common viral by-product originating during RNA virus replication, which is universally sensed as a danger signa...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024554 | Pride
Dsrna Sindbis virus Dsrnaome Sfpq Rbp 
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