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ProteomicsRegulation of mitophagy by Fis1 and Fascin1-organized actin
Mitophagy, the autophagic degradation of mitochondria, plays a central role in controlling the quality and quantity of mitochondria, thereby ensuring cellular health. The mitochondrial outer membrane protein Fis1 is important for several types of mitophagy, but its mechanism of action remains unclea...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-07 | PXD062948 | Pride
Mitophagy Fascin1 Fis1 Mitochondria Actin filaments 
ProteomicsTime-resolved proteomic analysis in zebrafish larvae using bioorthogonal noncanonical amino acid tagging (BONCAT)
Protein synthesis underpins many biological processes, yet tracking time-dependent proteomic changes remains challenging. Bioorthogonal noncanonical amino acid tagging (BONCAT) offers a targeted approach for labeling and identifying newly synthesized proteins within defined time windows of interest....
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-06-08 | PXD063084 | Pride
Boncat Heat shock Larval zebrafish Noncanonical amino acid tagging Protein synthesis Proteomics Click chemistry 
ProteomicsDifferential Impact of p97 Inhibitor CB-5083 on Protein Dynamics in Nucleus, Cytoplasm, and Membrane Compartments
Human p97/VCP is a vital AAA ATPase (ATPase associated with diverse cellular activity) plays critical roles in autophagy, endosomal trafficking, and the ubiquitin-proteasome system. Mutations in p97 cause inclusion body myopathy associated with paget’s disease of bone and frontotemporal dementia. P9...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056029 | Pride
P97 vcp P97 inhibitor  mass spectrometry. Cb-5083 
ProteomicsPutative PINK1/Parkin activators cause mitochondrial stress and lower the threshold for mitophagy
The PINK1/Parkin pathway is responsible for targeting damaged mitochondria for degradation via mitophagy. Because genetic evidence links impaired mitophagy to Parkinson’s disease, pharmacologic enhancement of mitophagy represents a promising disease-modifying strategy. Here, we characterize two phar...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058150 | Pride
Mitochondria  mitophagy Autophagy  pink1/parkin pathway  mitochondrial stress  neurodegeneration  parkinson’s disease  integrated stress response (isr)  drug discovery  off-target toxicity. 
ProteomicsMass-spectrometry-based genetic analysis of lysosome-related organelle in the intestine of Caenorhabditis elegans
The nematode intestine is the primary site for nutrient uptake and storage as well as the synthesis of important molecules; parts of its functions rely on a type of lysosome-related organelle known as gut granules. However, aspects of the intestine are not well understood, including the exporting of...
ORGANISM(S): Caenorhabditis elegans 
2024-05-23 | PXD047792 | Pride
Adult Intestine Glo-1 Lysosome-related organelle Gonad 
ProteomicsThe Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links
Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the progression of colorectal cancer and inflammatory bowel disease. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links (ICLs) tha...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-11 | PXD055646 | Pride
Interstrand cross-link Colibactin Xenopus laevis 
ProteomicsRegulation of mitochondrial oxidative phosphorylation and venetoclax efficacy in AML via COX4I1
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, we conducted a cell signaling-focused CRISPR screen and identified cytochrome c oxidase subunit 4I1 (COX4I1) as a novel vulnerability in acute myeloid...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050739 | Pride
Leukemia Cox4i1 Mitochondria 
ProteomicsHuman cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
Adeno-associated viruses (AAVs) are foundational gene delivery tools for basic science and clinical therapeutics. However, lack of mechanistic insight, especially for engineered vectors created by directed evolution, can hamper their application. Here, we adapted an unbiased human cell microarray pl...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD045380 | Pride
Interleukin-3 Aav9 Il3 
ProteomicsSingle cell analysis for oocytes and early embryos
While non-mammalian embryos often rely on spatial pre-patterning, for decades it was believed that blastomeres of mouse and human embryos were developmentally equivalent. However, emerging evidence suggests early mouse and human blastomeres differ in developmental potential. Here, using multiplexed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-08-10 | MSV000098778 | MassIVE
ProteomicsStructure of Anabaena flos-aquae gas vesicles revealed by cryo-ET
Gas Vesicles (GVs) are gas-filled protein nanostructures employed by several species of bacteria and archaea as flotation devices to enable access to optimal light and nutrients. The unique physical properties of GVs have led to their use as genetically-encodable contrast agents for ultrasound and M...
ORGANISM(S): Dolichospermum flos-aquae 04-10 
2023-03-30 | PXD038631 | Pride
Cryo-et. Gas vesicles 
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