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TranscriptomicsThe translational landscape of mTOR signaling steers cancer initiation and metastasis
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Employing riboso...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35469 | biostudies-arrayexpress
ProteomicsPharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Astrocytes contain the majority of the brain’s supply of glycogen which has been suggested to play an important role in neuronal synaptic plasticity. This may be mediated by release of glycogen-derived lactate or glutamine supporting neuronal metabolism or via induction of neuronal signaling pathway...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2021-08-13 | PXD027901 | Pride
Mouse astrocytes Amp-activated protein kinase Energy metabolism Adenylyl cyclase Phosphorylation 
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
UnknownHigh-frequency time series comparison of Sentinel-1 and Sentinel-2 satellites for mapping open and vegetated water across the United States (2017-2021).
Not available
S-EPMC10303792 | biostudies-literature
TranscriptomicsKDM6B-induced gene expression changes in transfected CD10-positive GC B cells
In this study, we have investigated the effect of lysine-specific demethylase 6B (KDM6B) on gene expression in normal human germinal center (GC) B cells using a non-viral vector-based system. Gene expression was compared between KDM6B-transfected and control vector-transfected GC B cells from three ...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-24044 | biostudies-arrayexpress
UnknownA review of ecosystem services from edge-of-field practices in tile-drained agricultural systems in the United States Corn Belt Region.
Not available
S-EPMC11773691 | biostudies-literature
ProteomicsCellular signaling underlying GSIS in pancreatic β-cells
In the present study, we investigated signaling pathways associated with GSIS in freshly isolated rat Islets of Langerhans. Specifically, our aim was to reveal which phosphosites and N-linked sialylated glycosylation sites that were reversible regulated upon brief glucose stimulation and link these ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-11-14 | PXD007689 | Pride
Beta-cells Lc-msms Gsis Rat Islets 
UnknownPotential of water quality wetlands to mitigate habitat losses from agricultural drainage modernization.
Not available
S-EPMC11773670 | biostudies-literature
ProteomicsBeta cell dysfunction and dedifferentiation induced by Bone Morphogenetic Protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by a decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from diabetic individuals and acts as an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036655 | Pride
Rna Histone Bmp-2 Proteomics 
UnknownEffect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs.
Not available
S-EPMC6461782 | biostudies-literature
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