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ProteomicsCD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) is a member of the TNFR family that mediates potent T-cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models and multiple agents of this kind are undergoing clinical trials. W...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042585 | Pride
4-1bb Smac mimetic compounds Cd137 Ciap1 Ciap2 Immunotherapy 
TranscriptomicsA signature of 6 genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) represents a major health problem as it afflicts an increasing number of patients worldwide. Albeit most of the risk factors for HCC are known, this is a deadly syndrome with a life expectancy at the time of diagnosis of less than 1 year. Definition of the molecular pr...
ORGANISM(S): Mus musculus 
2011-04-22 | E-GEOD-25457 | biostudies-arrayexpress
ProteomicsBiomarkers of Cholangiocarcinoma and Pancreatic adenocarcinoma
Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses can also be caused by benign conditions, and the identification of their etiology still remains a clinical challenge. We performed metabolomic ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019924 | Pride
Human bile  cholangiocarcinoma  pancreatic adenocarcinoma  lipidomics  proteomics  machine learning 
ProteomicsChr16-HPP.Pilot experiment.JPR HPP Special issue
"The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To characterize t...
ORGANISM(S): Homo sapiens (Human) 
2013-01-11 | PXD000039 | Pride
Human "hpp Miape" 
TranscriptomicsExpression profile of MCF7, CCD18 and Ramos human cell lines
To uncover the chromosome 16 associated proteome and to take advantage of the generated knowledge to make progress in human biology in health and disease, a consortium of 15 groups was organized in four working groups: SRM and protein sequencing, antibody and peptide standard, clinical healthcare an...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-40168 | biostudies-arrayexpress
UnknownIdentification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.
Not available
S-EPMC2667359 | biostudies-literature
ProteomicsAptamer-conjugated gold nanoparticles enable selective oligonucleotide delivery into muscle 2 stem cells to promote regeneration of dystrophic muscles
Inefficient targeting of muscle stem cells (MuSCs) represents a major bottleneck of current 27 therapeutic strategies for muscular dystrophies, as it precludes the possibility to promote 28 compensatory regeneration. Here we describe a novel delivery platform, based on gold nanoparticles, 29 that en...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD049295 | Pride
Gold nanoparticles Selex Proteomics Oligonucleotide Duchenne muscular dystrophy Aptamer 
UnknownHSV-1 Cgal+ infection promotes quaking RNA binding protein production and induces nuclear-cytoplasmic shuttling of quaking I-5 isoform in human hepatoma cells.
Not available
S-EPMC3108845 | biostudies-literature
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. Jurkat Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo sapiens (Human) 
2013-09-05 | PXD000443 | Pride
Chromosome centric Networking Miape Hpp 
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. MCF7 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo sapiens (Human) 
2013-09-04 | PXD000442 | Pride
Chromosome centric Networking Miape Hpp 
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