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ProteomicsMethyltioadenosine regulates liver cells proteome and methylproteome. Implications in liver biology and disease.
Methylthioadenosine phosphorylase (MTAP), a key enzyme in the adenine and methionine salvage pathways, catalyzes the hydrolysis of methylthioadenosine (MTA), a compound suggested to affect pivotal cellular processes in part through the regulation of protein methylation. MTAP is expressed in a wide r...
ORGANISM(S): Homo sapiens (Human) 
2016-02-01 | PXD002957 | Pride
Human Methylation Mta Liver Msms 
ProteomicsMolecular insights of cholestasis in MDR2KO murine liver organoids. A model for the early detection of cirrhosis and HCC
MDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by an early onset of intrahepatic cholestasis, progressing to liver cirrhosis which is considered a preneoplastic condition, ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-17 | PXD047995 | Pride
Pfic3 Mdr2 Cholestasis and hepatocellular carcinoma Organoid 
ProteomicsDiscrimination of etiologically different cholestasis by modeling proteomics datasets
Cholestasis is characterized by disrupted bile flow from the liver to the small intestine. Although etiologically different cholestasis display similar symptoms, diverse factors can contribute to the progression of the disease and determines the appropriate therapeutic option. Therefore, stratifying...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047823 | Pride
Human Liver Cholestasis 
ProteomicsTargeted quantitative analysis of specific proteins in cytosolic, mitochondrial, and nuclear fractions using PRM
We present a targeted proteomic approach using parallel reaction monitoring (PRM) to assess the enrichment of cytosolic, mitochondrial, and nuclear fractions obtained from liver samples using commercial isolation kits. For mitochondrial fraction, CPS1 and ATP5F1 were chosen. For the cytosolic fracti...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD067737 | Pride
Mitochondrial enrichment Liver Prm Subcellular fractionation Target proteomic 
ProteomicsProteomic profiling of human mesenchymal stem cells derived from umbilical cord or adipose tissue
We performed a proteomic profiling of human mesenchymal stem cells (hMSCs) derived from adipose tissue or umbilical cord.
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009893 | Pride
Adipose tissue Human mesenchymal stem cells Hmscs Umbilical cord 
ProteomicsBiomarkers of Cholangiocarcinoma and Pancreatic adenocarcinoma
Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses can also be caused by benign conditions, and the identification of their etiology still remains a clinical challenge. We performed metabolomic ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019924 | Pride
Human bile  cholangiocarcinoma  pancreatic adenocarcinoma  lipidomics  proteomics  machine learning 
TranscriptomicsExpression profile of MCF7, CCD18 and Ramos human cell lines
To uncover the chromosome 16 associated proteome and to take advantage of the generated knowledge to make progress in human biology in health and disease, a consortium of 15 groups was organized in four working groups: SRM and protein sequencing, antibody and peptide standard, clinical healthcare an...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-40168 | biostudies-arrayexpress
TranscriptomicsA signature of 6 genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) represents a major health problem as it afflicts an increasing number of patients worldwide. Albeit most of the risk factors for HCC are known, this is a deadly syndrome with a life expectancy at the time of diagnosis of less than 1 year. Definition of the molecular pr...
ORGANISM(S): Mus musculus 
2011-04-22 | E-GEOD-25457 | biostudies-arrayexpress
ProteomicsHs_C-HPP_Ramos_Organella
C-HPP, lymphocytic B-cell line (Ramos), Organella
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005400 | PeptideAtlas
ProteomicsHs_C-HPP_Ramos_Membrane
C-HPP, lymphocytic B-cell line (Ramos), Membrane
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005366 | PeptideAtlas
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