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ProteomicsAge-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Host defense against bacterial and fungal infections diminishes with age. In humans, this is thought to be caused in part by a decline in neutrophil responses. However, it remains unclear whether a similar decline in neutrophil function occurs in mice. Here, we show that old mice have a reduced capa...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-20 | PXD035577 | Pride
Tlr4 Phagocytosis Nets Degranulation Neutrophils Ros Aging 
ProteomicsThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav and Dock families. In this study, we demonstrate that Tia...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046791 | Pride
Tiam1 Dock2 Vav Neutrophils Rac Prex1 Rac-gef Small gtpase 
UnknownLymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma.
Not available
S-EPMC10193529 | biostudies-literature
ProteomicsSARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 non-structural protein 15 (nsp15) enhances viral virulence by suppressing the production of viral double-stranded (dsRNA), a potent inducer of antiviral signa...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD056702 | Pride
Nsp15 Sars-cov-2 
UnknownAntigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Not available
S-EPMC8522630 | biostudies-literature
UnknownImpact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
Not available
S-EPMC10750313 | biostudies-literature
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