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ProteomicsDual role of PCNA-monoubiquitination in facilitating Fanconi Anemia-mediated interstrand crosslink repair
The Fanconi Anemia (FA) repair pathway governs the repair of highly genotoxic DNA interstrand crosslinks (ICLs) with the assistance of translesion synthesis (TLS), that is facilitated by site-specific monoubiquitination of PCNA (PCNA-Ub) at lysine 164 (K164). Mutation at this residue (K164R) renders...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD035337 | Pride
Lc-msms Rime Interstrand crosslink repair Mouse Dna damage tolerance Mismatch repair Fanconi anemia Pcna ubiquitination 
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
GenomicsThe cullin Rtt101 promotes ubiquitin-dependent DNA-Protein Crosslink repair across the cell cycle
The cullin Rtt101 promotes ubiquitin-dependent DNA-Protein Crosslink repair across the cell cycle
PRJNA1038787 | ENA
UnknownC17orf53 is identified as a novel gene involved in inter-strand crosslink repair.
Not available
S-EPMC7669678 | biostudies-literature
ProteomicsCooperation of the NEIL3 and Fanconi Anemia/BRCA Pathways in Interstrand Crosslink Repair
The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 participants in ICL repair in human cells and its corporation with the canonical Fanconi anemia (FA...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD016256 | Pride
Neil3 Psoralen interstrand crosslink Fanconi anemia 
UnknownRNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.
Not available
S-EPMC4884500 | biostudies-literature
UnknownFanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development.
Not available
S-EPMC10584689 | biostudies-literature
ProteomicsPARP1-dependent DNA-protein crosslink repair
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also involved remains elusive. Here, we identify a DPC repair pathw...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-06 | PXD043107 | Pride
Xenopus Parp1 Top1 Dna-protein crosslink Adp-ribosylation Ddi2 Dna damage Ubiquitin Sumo P97 
UnknownDeubiquitination of FANCD2 is required for DNA crosslink repair.
Not available
S-EPMC2148256 | biostudies-literature
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
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