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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
ProteomicsCSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
Extracellular vesicles (EVs) are released by neurons and glia reach the cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel perspective on the key intracellular processes associated with the pathogenesis of the neurodegenerative disease amyotrophic lateral sclerosis (A...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020499 | Pride
Csf Als 
ProteomicsIdentification of novel CSF biomarkers in GRN-associated frontotemporal dementia by proteomics
Frontotemporal dementia is the second most common form of presenile dementia and autosomal dominant inheritance is present in 20-30% of cases, with mutations in granulin (GRN) as a major cause. The exact pathophysiological mechanism by which GRN mutations lead to neurodegeneration is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2019-04-29 | PXD012179 | Pride
Proteomics Prm Mass spectrometry Frontotemporal dementia Biomarkers Progranulin 
ProteomicsMolecular markers in the CSF proteome differentiate neuroinflammatory diseases
Manuscript "Molecular markers in the CSF proteome differentiate neuroinflammatory diseases" by Maria L. Elkjaer Arkadiusz Nawrocki, Tim Kacprowski, Anja Hviid Simonsen, Romain Marignier, Tobias Sejbaek, Helle H. Nielsen, Lene Wermuth, Peter Høgh, Finn Sellebjerg, Richard Reynolds, Jan Baumbach, Mart...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD017643 | Pride
Human csf Multiple sclerosis Proteomics 
ProteomicsMOUSE CSF Parallel Reaction Monitoring
MOUSE CSF PRM Mecp2 - 20 samples with AQUA standards
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD029835 | Pride
Mouse Prm Csf 
UnknownComparative evaluation of analytical methods for CSF proteomics.
Not available
S-EPMC12661759 | biostudies-literature
ProteomicsHuman Lyme Neuroborreliosis LC-MS (CSF)
Lyme neuroborreliosis (LNB) is a nervous system infection caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex and is one of the most frequent bacterial infections of the nervous system in Europe. Early diagnosis remains challenging due to limited sensitivity and specifici...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD067474 | Pride
Human Lc-ms Csf Borreliosis Lnb 
ProteomicsLarge scale cerebrospinal fluid proteomics reveals biomarkers of Multiple Sclerosis
Cerebrospinal fluid (CSF) plays critical roles in clinical diagnostics, offers a window into neuropathological mechanisms and is available at scale. To enable its large-scale proteomics characterization, we developed a high-throughput mass spectrometry-based workflow based on the Orbitrap Astral. T...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD064570 | Pride
Multiple sclerosis Body fluids Astral Csf Biomarkers 
ProteomicsLong term intrathecal administration of morphine vs baclofen: differences in CSF identified using multi-glycomics
CSF samples from patients that had long-term (>2years), intrathecal morphine or baclofen administered via an indwelling pump, and we performed proteomics and multi-glycomics via sequential release of polysialic acids, glycosaminoglycans, N-glycans and O-glycans from the same sample material.
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD023111 | Pride
Multi-glycomics Csf Intrathecal Morphine Long-term 
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