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ProteomicsQuantitative proteomic analysis of the Toxoplasma gondii cytoskeleton and bioinformatic identification of highly antigenic proteins
The Toxoplasma gondii cytoskeleton is a highly organized structure essential for parasite motility, replication, and host cell invasion. To identify its components, a highly enriched fraction of tachyzoite cytoskeletons was obtained and quantitatively analyzed by mass spectrometry (LC/ESI/HDMSE). We...
ORGANISM(S): Eukaryota Toxoplasma gondii RH 
2025-08-04 | PXD063409 | Pride
Toxoplasma gondii Quantitative mass spectrometry Immunogenic peptides Cytoskeleton 
TranscriptomicsTranscription profiling of social amoeba Dictyostelium discoideum wildtype and srfB knock-out strains detects significant differences in the expression of genes coding for proteins involved in cytoskeleton regulation and developmentally-regulated genes
Microarray analyses of genes differentially expressed in WT and srfBKO strains detected significant differences in the expression of genes coding for proteins involved in cytoskeleton regulation and in developmentally-regulated genes.
ORGANISM(S): Dictyostelium discoideum 
2008-11-03 | E-TABM-407 | biostudies-arrayexpress
TranscriptomicsGPM6B regulates osteoblast differentiation and induction of mineralization by controlling cytoskeleton and matrix vesicle release.
Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26004 | biostudies-arrayexpress
TranscriptomicsImmunopurification results of cytoskeletal motor proteins in S. cerevisiae
The accompanying dataset is the result of a systematic study to identify the RNA cargoes associated with the cytoskeletal motor proteins of Saccharomyces cerevisiae. We immunopurified, via the use of integrated, C-terminal GFP and 9Myc tags, the five actomyosin motors, Myo1, Myo2, Myo3, Myo4, and My...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-27 | E-GEOD-35343 | biostudies-arrayexpress
ProteomicsCytoskeleton-associated protein 4 (CKAP4) affects podocyte cytoskeleton dynamics in diabetic kidney disease.
Cytoskeleton-associated protein 4 (CKAP4) stabilizes the endoplasmic reticulum, by regulating its folding and anchoring to the microtubular cytoskeleton. Since podocytes are highly dependent on an intact cytoskeleton to exert their function, the role of CKAP4 was explored during normal conditions an...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD046643 | Pride
Cytoskeleton Diabetic kidney disease Integrins Podocytes Microtubules Ckap4 
ProteomicsThe Trichomonas PACK proteome - The Cytoskeleton of Parabasalian Parasites Comprises Proteins that Share Properties Common to Intermediate Filament Proteins
Certain protist lineages bear cytoskeletal structures that are germane to them and define their individual group. Trichomonadida are excavate parasites united by a unique cytoskeletal framework, which includes tubulin-based structures such as the pelta and axostyle, but also other filaments such as ...
ORGANISM(S): Tetratrichomonas gallinarum 
2016-10-10 | PXD003212 | Pride
Lc-ms Cytoskeleton Evolution Tetratrichomonas gallinarum 
ProteomicsThe costa of trichomonads: A complex macromolecular cytoskeleton structure made of uncommon proteins
Background Information The costa is a prominent striated fiber that is found in protozoa of the Trichomonadidae family that present an undulating membrane. It is composed primarily of proteins that have not yet been explored. In this study, we used cell fractionation to obtain a highly enriched cos...
ORGANISM(S): Tritrichomonas foetus 
2017-04-04 | PXD005915 | Pride
Cytoskeleton Mass spectrometry Coiled-coils Trichomonas vaginalis Tritrichomonas foetus 
UnknownTargeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.
Not available
S-EPMC3566231 | biostudies-literature
UnknownDynamic motions of molecular motors in the actin cytoskeleton.
Not available
S-EPMC7439601 | biostudies-literature
ProteomicsSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and alpha-actinin, linking innate immunity to the cytoskeleton
Suppressor of IKKepsilon (SIKE) is associated with the innate immune system’s type I interferon response through TANK binding kinase 1 (TBK1). Characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, mechanistic study revea...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD007262 | Pride
Innate immunity Cytoskeleton Sike Tubulin Alpha-actinin 
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