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ProteomicsNeutrophils display novel cytosolic proliferating cell nuclear antigen (PCNA) partners involved in interferon response in COVID-19
Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection, exhibiting features of deregulation and reprogramming. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and known to interact wit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055810 | Pride
Interferon Neutrophils Neutrophils extracellular traps Covid-19 Pcna 
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
ProteomicsCompetitive Binding and Molecular Crowding Regulate the Cytoplasmic Interactome of Non-Viral Polymeric Gene Delivery Vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028512 | Pride
Gene delivery Rna delivery Polymer brush Proteomics Cytosolic interactome Polycationic vector Lc-ms/ms 
ProteomicsMapping the cytosolic proteins of HEK293T cells
N-terminal proteoforms stem from the same gene but differ at their N-terminus, and most of these are found to be truncated, though some are N-terminally extended caused by ribosomes starting translation from codons in the annotated 5’UTR, and/or carry modified N-termini different from those of the c...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039127 | Pride
Cytosol Fractionation Hek293t cells Lc-ms/ms 
ProteomicsMapping the Toxoplasma gondii cytosolic interactome by crosslinking mass spectrometry and machine learning
Protein–protein interactions (PPIs) are fundamental to cellular processes and pathogen biology, yet remain undercharacterized in the human parasite Toxoplasma gondii. Here, we apply crosslinking mass spectrometry (XL-MS) to map the cytosolic interactome of T. gondii tachyzoites at proteome scale. Us...
ORGANISM(S): Toxoplasma gondii type I 
2025-07-26 | PXD062479 | Pride
Machine learning Cytosol Protein–protein interactions Dense granule proteins Crosslinking mass spectrometry Interactome Dsbso Host-pathogen interactions Structural mapping Toxoplasma gondii Lightgbm Parasite proteomics Ribosome Proteasome 
UnknownIn vivo structure profiling reveals human cytosolic and mitochondrial tRNA structurome and interactome in response to stress.
Not available
S-EPMC12125218 | biostudies-literature
ProteomicsPan-claudin family interactome analysis reveals shared and specific interactions
Interactome study of the pan-claudin family by combining two complementary pull-down techniques followed by mass spectrometry to create an interaction landscape of the claudin family. Co-immunoprecipitation (CoIP) of recombinant claudins expressed in MDCK-C7 cells provided information about interact...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2023-10-24 | PXD031094 | Pride
Lc-ms/ms Prisma Claudin Pulldown Interactome Peptide pulldown 
UnknownSpatiotemporal profiling of cytosolic signaling complexes in living cells by selective proximity proteomics.
Not available
S-EPMC7782698 | biostudies-literature
UnknownThe interactome of 2-Cys peroxiredoxins in Plasmodium falciparum.
Not available
S-EPMC6753162 | biostudies-literature
ProteomicsLC-MS MS of Interactome of overexpressed FKBPL in HEK293T cells
We identified a cytosolic ER-phagy receptor FKBPL. For further identification for binding partner of FKBPL resident at the ER, interactome of FKBPL were analysed with LC-MS/MS assay.
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD034980 | Pride
Lc-msms 
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