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ProteomicsTrans-branching of polyubiquitin chains orchestrates the DNA replication stress response
Polyubiquitin chain geometry dictates functional consequences of ubiquitylation. Although branched polyubiquitin chains are abundant in cells, little is known about their functions. Here we show that branching on the DNA replication factor PCNA, mediated by the ubiquitin-conjugating enzyme UBE2K and...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD054064 | Pride
Brca1 Polyubiquitin chain branching Pcna Synthetic lethality Daughter-strand gap Vcp/p97 Usp1 Ube2k K63-linkage Ubiquitin K48-linkage Dna damage bypass Genome stability Polyubiquitin chain linkage Re-priming 
UnknownThe INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
Not available
S-EPMC12624141 | biostudies-literature
UnknownThe INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair
Not available
S-SCDT-10_1038-S44318-025-00580-4 | biostudies-other
UnknownAnalysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in Escherichia coli: predominance of strand transfer.
Not available
S-EPMC4193903 | biostudies-literature
UnknownRecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes.
Not available
S-EPMC10287930 | biostudies-literature
UnknownRecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
Not available
S-EPMC10287957 | biostudies-literature
UnknownSpatial separation between replisome- and template-induced replication stress signaling.
Not available
S-EPMC5920239 | biostudies-literature
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
UnknownDysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.
Not available
S-EPMC16647 | biostudies-literature
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