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ProteomicsEpitope and Paratope Mapping of TNFα/Infliximab complex by cross-linking mass spectrometry and integrative modeling reveals high level of interaction specificity
Mass spectrometry (MS) has become one of the core technologies to study protein structures, protein-ligand and protein-protein interactions. Chemical cross-linking combined with mass spectrometry (XL-MS) is quickly spreading over different biochemistry laboratories for the continuous increase of its...
ORGANISM(S): Escherichia coli 
2024-02-27 | PXD043347 | Pride
Cross-linking mass spectrometry  monoclonal antibodies  integrative modeling  epitope/paratope mapping 
ProteomicsNHS Carbamate Cross-Linkers Provide Complementary XL-MS Restraints via Preferential N-Terminal Targeting
Cross-linking mass spectrometry (XL-MS) has become a valuable tool for investigating the structural morphology and plasticity of proteins. Traditional cross-linkers contain two N-hydroxy succinimide (NHS) esters that mainly react with lysine residues. In this work, we optimized the in-solution react...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-03-30 | PXD069252 | Pride
Crosslinking ms Cross-linking ms Dsso carbamate Nhs carbamate cross-linkers N-terminal reactivity Xl-ms Cross-linking mass spectrometry Ms-cleavable cross-linkers 
ProteomicsAssessing Major Histocompatibility Complex-Associated Peptide Proteomics assay as a tool to predict immunogenicity potential of protein therapeutics and antigens
Major histocompatibility complex-II (MHC-II)-Associated Peptide Proteomics (MAPPs) is a mass spectrometry-based approach, to identify and relatively quantitate naturally processed and presented MHC-II-associated peptides, that could potentially activate CD4+T cells and elicit a patient immune respon...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD037958 | Pride
Lc-msms Mapps Human 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 3)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066538 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066532 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 1)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066475 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsStructural Assessment of the Full-Length Tumor Suppressor Protein p53 by Mass Spectrometry-Guided Computational Modeling
The tetrameric tumor suppressor p53 represents a great challenge for 3D structural analysis due to its high degree of intrinsic disorder (ca. 40%). We developed and applied an integrative structural biology approach combining complementary techniques of structural mass spectrometry (MS), namely cros...
ORGANISM(S): Escherichia coli 
2023-06-26 | PXD037030 | Pride
Computational modeling  cross-linking mass spectrometry  dna binding  intrinsically disordered proteins  tumor suppressor p53 
ProteomicsMolecular recognition of thyroglobulin by sortilin
Sortilin is a ubiquitous membrane receptor mediating protein trafficking along different cellular routes. In the thyroid gland, sortilin was proposed as a post-endocytic receptor of the thyroid hormone precursor, thyroglobulin (TG). It was reported that sortilin preferably shuttles iodinated TG to t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD062462 | Pride
Thyroid Sortilin Cryo-em Thyroglobulin Cross-linking mass spectrometry Crosslinking mass spectrometry Crosslinking ms Trafficking Xl-ms Iodination Endocytosis 
UnknownDosing and clinical outcomes of ruxolitinib in patients with myelofibrosis in a real-world setting: Interim results of the Italian observational study (ROMEI).
Not available
S-EPMC11925231 | biostudies-literature
ProteomicsRevisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
The NAD⁺-dependent deacetylase sirtuin 1 (Sirt1) is known to regulate the tumor suppressor p53 via deacetylation, but the structural basis of the protein-protein interaction between full-length Sirt1 and p53 has so far remained elusive. We apply an integrated approach, combining structural mass spe...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072665 | Pride
Sirtuin 1 Cross-linking Mass spectrometry P53 
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