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ProteomicsIKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
Quantitative proteomic profiling of TPCA-1-treated bone marrow-derived macrophages stimulated with TNF-α (50 ng/mL) for 24 h. TNF-α was used as an endogenous pro-inflammatory stimulus and inducer of sterile inflammation.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036118 | Pride
Macrophages Tpca-1 Ikkβ Tnf-α 
ProteomicsA cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upo...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD042078 | Pride
Inflammation Inflammasome Atherosclerosis Hdac9 Nlrp3 
UnknownFunctional impairments for outcomes in a randomized trial of unruptured brain AVMs.
Not available
S-EPMC5631171 | biostudies-literature
UnknownNext generation sequencing analysis of patients with familial cervical artery dissection.
Not available
S-EPMC6453217 | biostudies-literature
UnknownHigher CSF sTREM2 and microglia activation associate with slower rate of beta-amyloid accumulation
Not available
S-SCDT-EMM-2020-12308 | biostudies-other
UnknownA unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.
Not available
S-EPMC9931915 | biostudies-literature
UnknownA high-density association screen of 155 ion transport genes for involvement with common migraine.
Not available
S-EPMC2566523 | biostudies-literature
UnknownGene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Not available
S-EPMC5541777 | biostudies-literature
UnknownCommon variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.
Not available
S-EPMC4351667 | biostudies-literature
UnknownGenome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
Not available
S-EPMC7116530 | biostudies-literature
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