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ProteomicsProteome of DiFi and CC-CR supermeres purified by FPLC with or without additional affinity purification for TGFBi
The cell seretome is diverse and contains extracellular secreted vesicles (EVs) as well as non-vesicular extracellular nanoparticles (NVEPs) called exomeres and supermeres, all of which carry different kinds of cell signaling cargos. One supermere enriched cargo is transforming growth factor beta in...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD066888 | Pride
Supermeres Fplc Affinity purification Proteomics 
ProteomicsProteome of DiFi EVs, exomeres and supermeres purified by ultracentrifugation and FPLC
The cell seretome is diverse and contains extracellular secreted vesicles (EVs) as well as non-vesicular extracellular nanoparticles (NVEPs) called exomeres and supermeres, all of which carry different kinds of cell signaling cargos. We have developed new techniques to purify exomeres and supermeres...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD066872 | Pride
Supermeres Exosomes Ultracentrifugation Fplc Proteomics Exomeres Extracellular vesicles 
TranscriptomicsGlobal gene expression analysis between cetuximab-sensitive and cetuximab-resistant colorectal cancer cells
Cetuximab is an epidermal growth factor receptor (EGFR)-blocking antibody approved for treatment of metastatic colorectal cancer. We examined differences in global gene expression between the syngeneic DiFi colorectal cancer cells, and a subline of DiFi cells with acquired resistance to cetuximab (D...
ORGANISM(S): Homo sapiens 
2016-07-17 | E-GEOD-71210 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis between cetuximab-sensitive and cetuximab-resistant colorectal cancer cells
Cetuximab is an epidermal growth factor receptor (EGFR)-blocking antibody approved for treatment of metastatic colorectal cancer. We examined differences in global gene expression between the syngeneic DiFi colorectal cancer cells, and a subline of DiFi cells with acquired resistance to cetuximab (D...
ORGANISM(S): Homo sapiens 
2016-07-17 | GSE71210 | GEO
ProteomicsA systematic comparison of label-free, SILAC and TMT techniques to study early adaption towards inhibition of EGFR signaling in the colorectal cancer cell line Difi
The epithelial growth factor receptor (EGFR) signalling network plays an essential role inproliferation and survival of colorectal cancer cells. For this reason, EGFR is targeted using therapeutic antibodies blocking EGFR signalling (e.g. cetuximab). However, anti-EGFR therapy is rarely curative as ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-11 | PXD014565 | Pride
Phosphoproteomics Tmt Anti-egfr therapy Colorectal cancer Silac Mapk Label-free Erbb3 Adaptive mechanism Cetuximab 
GenomicsSupermeres, a new functional extracellular nanoparticle replete with disease biomarkers and therapeutic targets
RNA-Seq of cellular and extracellular samples from DiFi cells. The distribution of extracellular RNA among cells, sEV pellet, exomeres and supermeres is distinct.
ORGANISM(S): Homo sapiens 
2021-10-12 | GSE168416 | GEO
UnknownSemi-supervised data-integrated feature importance enhances performance and interpretability of biological classification tasks.
Not available
S-EPMC12261460 | biostudies-literature
UnknownThe anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells.
Not available
S-EPMC4323007 | biostudies-literature
ProteomicsSupermeres, a new functional extracellular nanoparticle replete with disease biomarkers and therapeutic target
Extracellular vesicles, including exosomes, and exomere nanoparticles, are under intense investigation for cargo that may serve as clinical biomarkers or therapeutic targets. Here, we report discovery of a new extracellular nanoparticle, termed supermeres. We performed LC/MS-MS proteomics analyses o...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD025213 | Pride
Human Sev Supermere Exomere Difi Colorectal cancer Lc-ms/ms 
UnknownIdentification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting.
Not available
S-EPMC4921784 | biostudies-literature
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