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ProteomicsProteome analysis and targeted proteolysis identify a developmentally relevant COPS3 deposit in mouse oocytes
An important facet of the oocyte to embryo transition in mammals is the rapid elimination of a subset of the maternal products that got accumulated during oogenesis. RNA studies support a view that the transition occurs quite rapidly. Whether this applies also for proteins remains to be determined b...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-22 | PXD017212 | Pride
Lc-msms Proteomics Oocyte Silac Mouse Label-free quantification 
ProteomicsDynarrestin, a novel inhibitor of cytoplasmic dyneins 1 and 2
Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Currently available inhibitors target Smoothened, which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smoothened are urgently needed. We identified dynarrest...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-08 | PXD004440 | Pride
Hedgehog signalling Small molecule inhibitor Dynein Dynarrestin 
ProteomicsThe ubiquitin landscape of the Influenza A Virus polymerase
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and functionally explore the ubiquitin landscape of the IAV polymerase during infection of human alveolar epithelial cells by applying mass spectrometry an...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/Wilson-Smith/1933(H1N1)) 
2023-03-11 | PXD030816 | Pride
Influenza a virus Pb1 Affinity enrichment Pa Viral rna-dependent rna polymerase Ubiquitination K-ε-gg motif Lc-msms Pb2 
ProteomicsVascular endothelial protein tyrosine phosphatase: Identification of novel cell junction-related substrates and a ternary receptor complex with EPHB4 and TIE2
Vascular endothelial protein tyrosine phosphatase (VE-PTP, PTPRB) is a receptor type phosphatase that is crucial for the regulation of endothelial junctions and blood vessel development. VE-PTP regulates vascular integrity by dephosphorylating substrates which are key players in endothelial junction...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-20 | PXD011940 | Pride
Lc-msms Mouse Tyrosine phosphatase Endothelial cells Substrate trapping 
ProteomicsTalin force coupling underlies eukaryotic cell-substrate adhesion
Integrin-mediated cell adhesion and mechanotransduction are considered key innovations in animal evolution, enabling a specific and physically robust attachment of cells to the extracellular environment. Here, we show that this type of cell adhesion is a specification of an evolutionary conserved fo...
ORGANISM(S): Homo sapiens (Human) Dictyostelium discoideum (Slime mold) 
2025-11-21 | PXD062078 | Pride
Mechanotransduction Mass spectrometry Evolution Talin Adhesion Dictyostelium Integrin 
ProteomicsHeading towards a dead end: the role of DND1 in germ line differentiation of human iPSCs
The DND microRNA-mediated repression inhibitor 1 (DND1) is a conserved RNA binding protein (RBP) and plays an important role in survival and maintenance of primordial germ cells (PGCs) and the development of the male germline in zebrafish and mice. It was shown to be expressed in human pluripotent s...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD023802 | Pride
Primordial germ cells Proteomics Mass spectrometry Dnd1 Differentiation Human pluripotent stem cells 
ProteomicsA balanced Oct4 protein interaction network is crucial for maintaining pluripotency
Oct4 is considered a master transcription factor for pluripotent cell self-renewal and embryo development. It primarily collaborates with other transcriptional factors or coregulators to maintain pluripotency. However, it is still unclear how Oct4 interacts with its partners. Here, we show that the ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-10 | PXD017456 | Pride
Oct4 Embryonal development Proteomics Pluripotency Mass spectrometry Transcription factor Pou5f1 Stem cells Protein-protein interaction 
ProteomicsDROSOPHILA FUS MUTANT PHENOTYPES ARE MEDIATED BY INCREASED XRP1 EXPRESSION LEADING TO GENE EXPRESSION DYSREGULATION
Several RNA-binding proteins (RBPs) are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), including the FET proteins FUS, TAF15 and EWSR1. Cabeza (caz) is the single Drosophila FET ortholog. Here, we identified Xrp1, a poorly characterized DNA-binding protein, as a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-09-06 | PXD008417 | Pride
Drosophila Fus At-hook motif Frontotemporal dementia Amyotrophic lateral sclerosis Gene expression regulation 
ProteomicsThe trade-off hypothesis of oocyte quantity and quality in gonadotropin-stimulated ovarian regime: proteome profile of superovulated vs naturally ovulated mouse oocytes
In order to clarify if there is a tradeoff between quantity and quality of oocytes retrieved after ovarian stimulation, we compared the protein expression of mouse oocytes and embryos with vs without a background of ovarian stimulation using gonadotropins, administered according to the standard prot...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-14 | PXD026347 | Pride
Lc-msms Ovulation Proteomics Oocytes Gonadotropin Super-ovulation Isobaric tag 
ProteomicsThe trade-off hypothesis of oocyte quantity and quality in gonadotropin-stimulated ovarian regime: proteome profile of superovulated vs naturally ovulated mouse oocytes
In order to clarify if there is a tradeoff between quantity and quality of oocytes retrieved after ovarian stimulation, we compared the protein expression of mouse oocytes and embryos with vs without a background of ovarian stimulation using gonadotropins, administered according to the standard prot...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-15 | PXD021331 | Pride
Proteomics Oocyte Ovarian stimulation Gonadotropin Lc-msms 
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