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ProteomicsPGC-1alpha mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
Human rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower airways diseases. Although viral induced epithelial damage mediates inflammation, the molecular mechanisms responsible for airway epithelial damage and dysfunction remain undefined. Using experimental HRV infecti...
ORGANISM(S): Viruses Homo sapiens (Human) 
2021-04-30 | PXD024591 | Pride
Metabolism Lung Virus Airway 
MetabolomicsExpanding the clinical use of DBS: through a metabolomic and a lipidomic evaluation

Personalized medicine aims to tailor healthcare to individual characteristics, relying on precise biological data and patient monitoring. Metabolomics and lipidomics play a key role in this approach, providing real-time insights into metabolic states and enabling accurate diagnosis and treatment ...

2026-02-25 | MTBLS13382 | MetaboLights
ProteomicsNasal septum deviation as the consequence of BMP-controlled changes to cartilage properties
Nasal septum deviation (NSD) is a common abnormality of the septal cartilage often associated with disordered breathing. The etiology of NSD is unknown. BMP7 neural crest-knockout mice, a well-characterized model for midfacial hypoplasia and nasal airway obstruction, develops a deviated septum by 4 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-30 | PXD024813 | Pride
Septum Cartilage Bmp 
ProteomicsProteomics analysis of tears and saliva from Sjogren’s syndrome patients
Sjogren’s syndrome (SS) is characterized by dysfunctional mucous membranes and dysregulated moisture-secreting glands resulting in various symptoms, including dry mouth and dry eyes. Here, we wanted to profile and compare the tears and saliva proteomes of SS patients to healthy controls. Tear and sa...
ORGANISM(S): Homo sapiens (Human) 
2021-10-04 | PXD028922 | Pride
Proteoglycan 4 Lubricin Proteomics Sjogren’s syndrome Protease Protease inhibitor Prg4 Saliva Tears 
ProteomicsMesenchymal stem cells from an inflammed area and normal tissue post anterior cruciate ligament injury
Mesenchymal stem cells from an inflammed area and a uninflammed tissue post anterior cruciate ligament injury
ORGANISM(S): Homo sapiens (Human) 
2021-10-04 | PXD026787 | Pride
Inflammation Acl Stem cells Msc 
ProteomicsActive thrombin is produced by intestinal epithelium to control mucosal biofilm
Healthy human and mouse colon epithelium is a major source of active thrombin, released in lumen. Using germ-free animals, we demonstrated that mucosal thrombin was directly regulated by the presence of commensal microbiota. Specific inhibition of lumenal thrombin activity caused macro-, microscopic...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD014315 | Pride
Gut physiology Thrombin Microbial biofilm Microbiota spatial organization Epithelia 
ProteomicsN-terminomics/TAILS profiling of proteases and their substrates in ulcerative colitis
Dysregulated protease activity is often implicated in the initiation of inflammation and immune cell recruitment in gastrointestinal inflammatory diseases. Using N-terminomics/TAILS (terminal amine isotopic labeling of substrates), we compared proteases, along with their substrates and inhibitors, b...
ORGANISM(S): Homo sapiens (Human) 
2019-09-08 | PXD014479 | Pride
Protease Biopsies Ulcerative colitis Tails 
ProteomicsThe Identification of Proteolytic Substrates of Calpain-5 with N-terminomics
Calpain-5/CAPN5 is a calcium-activated, non-lysosomal cysteine (thiol) protease. The substrate spectrum repertoire of CAPN5 is not known. Calpains catalyze limited proteolysis of their substrates, generating novel neo protein N-termini that correspond to internal residues of their nascent substrate ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064313 | Pride
Capn5 Protease Disease Tails N-terminomics Calpain-5 
ProteomicsExercise Proteomics LPC mouse models
Exercise has the potential to significantly impact those suffering from autoimmune and inflammatory diseases including multiple sclerosis (MS). However, persons with multiple sclerosis (PwMS) do not engage in sufficient activity due to barriers such as increased fatigue, reduced mobility and disabil...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD020782 | Pride
Lpc Mouse Serum Multiple sclerosis Spinal cords 
ProteomicsRat heart proteomics in a spinal cord injury
The vascular functions of rat hearts were tested using shotgun proteomics in a model of spinal cord injury.
ORGANISM(S): Rattus norvegicus (Rat) 
2022-01-17 | PXD026707 | Pride
Heart Rat Spinal cord injury Spinal cord 
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