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ProteomicsStructural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts ...
ORGANISM(S): Human papillomavirus type 16 Homo sapiens (Human) 
2018-10-23 | PXD010002 | Pride
Xl-ms E6 oncoprotein Ubiquitin E6ap/ube3a P53 Papillomavirus 
ProteomicsMembers of the RhoA subfamily of Rho GTPases interfere with HPV E6-mediated stimulation of the ubiquitin ligase E6AP
The E3 ubiquitin ligase E6AP, encoded by the UBE3A gene, plays a prominent role in cancers induced by human papillomaviruses (HPVs). In complex with the HPV E6 oncoprotein, it targets for instance the tumor suppressor p53 for degradation, thereby contributing to HPV-induced cellular transformation. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069396 | Pride
E6ap Rhoa Hpv E6 Ube3a Ubiquitination Xl-ms 
ProteomicsMembers of the RhoA subfamily of Rho GTPases interfere with HPV E6-mediated stimulation of the ubiquitin ligase E6AP
The E3 ubiquitin ligase E6AP, encoded by the UBE3A gene, plays a prominent role in cancers induced by human papillomaviruses (HPVs). In complex with the HPV E6 oncoprotein, it targets for instance the tumor suppressor p53 for degradation, thereby contributing to HPV-induced cellular transformation. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069419 | Pride
E6ap Rhoa Hpv E6 Ube3a Lip-ms Ubiquitination 
ProteomicsMembers of the RhoA subfamily of Rho GTPases interfere with HPV E6-mediated stimulation of the ubiquitin ligase E6AP
The E3 ubiquitin ligase E6AP, encoded by the UBE3A gene, plays a prominent role in cancers induced by human papillomaviruses (HPVs). In complex with the HPV E6 oncoprotein, it targets for instance the tumor suppressor p53 for degradation, thereby contributing to HPV-induced cellular transformation. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069463 | Pride
E6ap Rhoa Hpv E6 Ube3a Ubiquitination Mass spectrometry In-gel 
TranscriptomicsChanges in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells
We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E- Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-A cells. A...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-73761 | biostudies-arrayexpress
UnknownTargeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand.
Not available
S-EPMC4512291 | biostudies-literature
ProteomicsProteomic Analysis of the E6 Interactome in Response to Anisomelic Acid Treatment
Human papillomavirus (HPV) is a well-known cause of cervical cancer, with the viral oncoprotein E6 playing a key role in carcinogenesis. We previously showed that anisomelic acid treatment reduces E6 protein levels in HPV-positive cancer cells. In this study, we used mass spectrometry-based proteomi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD065382 | Pride
Lc-ms/ms Anisomelic acid Normal oral keratinocytes Hpv16 e6 
UnknownDetection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay.
Not available
S-EPMC7176116 | biostudies-literature
UnknownRole of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination.
Not available
S-EPMC4538620 | biostudies-literature
UnknownMolecular Landscape and Computational Screening of the Natural inhibitors against HPV16 E6 Oncoprotein.
Not available
S-EPMC8629474 | biostudies-literature
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