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ProteomicsMediator Kinase Complexes Regulates ATOH1-Dependent Intestinal Differentiation
Cyclin Dependent Kinases CDK8 and CDK19 (Mediator kinase) are regulatory components of the Mediator complex, a highly conserved complex that fine tunes transcriptional output. While Mediator kinase has been implicated in the transcriptional control of key pathways necessary for development and growt...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD030212 | Pride
Phosphoproetomics. cdk8 Cdk19 
ProteomicsDimethyl Sulfoxide Enhances HLA Peptide Identification
Immunopeptidomics relies on LC-MS/MS for comprehensive profiling of HLA-bound peptides, yet detection remains challenging due to their non-tryptic nature, variable lengths, and lack of basic residues, which limit ionisation and fragmentation efficiency. To address these limitations, we investigated ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072997 | Pride
Immunopeptidomics Dmso Supercharging 
ProteomicsSAPrIm 2.0: A semi-automated protocol for mid-throughput soluble HLA immunopeptidomics
Human leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process is central to the development of cancer immunotherapies, such as vaccines and T-cell therapies. Profil...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058880 | Pride
Shla Hla Mass spectrometry Mhc Saprim Immunopeptidomics Soluble hla Plasma immunopeptidomics 
ProteomicsSAPrIm, A Semi-Automated Protocol for mid-throughput Immunopeptidomics
Human leukocyte antigen (HLA) molecules play a crucial role in the development of adaptive immune responses and therefore have been of major interest in the development of immunotherapies such as cancer vaccines and chimeric antigen receptor (CAR) T cells. Hence, a comprehensive understanding and pr...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD041046 | Pride
Immunopeptidomics Human leukocyte antigen Kingfisher 
ProteomicsIFNγ modulates the immunopeptidome of triple negative breast cancer cells by enhancing and diversifying antigen processing and presentation.
Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumours. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-γ (IFNγ) on the transcriptome, proteome and immuno...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD023038 | Pride
Ifn gamma Triple negative breast cancer Proteomics Immunopeptidomics 
ProteomicsIFNγ modulates the immunopeptidome of triple negative breast cancer cells by enhancing and diversifying antigen processing and presentation.
Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumours. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-γ (IFNγ) on the transcriptome, proteome and immuno...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD023044 | Pride
Hla Breast cancer Immunopeptidomics 
ProteomicsImmunopeptidomics analysis of mesothelmia cell line
We have analysed a patinet derived mesothelioma cell line by immuniopeptidomics and identified cancer antignes in this line immunopeptidome.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD037845 | Pride
Immunopeptidomics mesothelmia hla proteomics erv 
ProteomicsThe self-peptide repertoire plays a critical role in transplant tolerance induction
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly-alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically-engineered MHC I constructs, mice with a hepatocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD023015 | Pride
Immunopeptidomics Hla Transplantation 
ProteomicsHLA-DQ8 Immunopeptidomics, Type 1 Diabetes
In this project we will investigate the peptides present by HLA-DQ8. We will identify linear, spliced and PTM peptides from one cell line.
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD019466 | Pride
Immunopeptidomics Type 1 diabetes Spliced 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstrat...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD017922 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
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